Reduced plasma C-20 and C-22 polyunsaturated fatty acids in children with phenylketonuria during dietary intervention

Calaudio Galli, Carlo Agostoni, Cristina Mosconi, Enrica Riva, Pier Carlo Salart, Marcello Giovannini

Research output: Contribution to journalArticlepeer-review

Abstract

The fatty acid composition of plasma and erythrocyte lipids was analyzed in 15 children with phenylketonuria (aged 3 to 12 years) during dietary treatment aimed to maintain plasma phenylalanine levels at less than 8 mg/dl (485μmol/L), and compared with those of 12 matched control subjects. The diet of children with phenylketonuria provided less protein, with a very low proportion of animal proteins, less fat, but a higher proportion of linoleic acid as a percentage of calories, and a higher carbohydrate content versus that in the diet of control subjects. The children with phenylketonuria had higher plasma levels of oleic acid but lower levels of arachidonic (n-6) and n-3 fatty acids. Linoleic and eicosatrienoic (n-9) acid levels were the same in both groups. These changes in patients with phenylketonuria resemble those observed in vegetarians and may be due to the absence of preformed arachidonic acid and long-chain n-3 fatty acids in the phenylketonuric diet.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalJournal of Pediatrics
Volume119
Issue number4
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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