Reduced plasma concectrations of transforming growth factor β1 (TGF-β1) in obese women

F. Corica, A. Allegra, M. Buemi, A. Corsonello, S. Bonanzinga, F. Rubino, L. Castagna, D. Ceruso

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Abstract

OBJECTIVE: To evaluate Transforming Growth Factor β1 (TGF-β1) plasma and the possible relationship between this growth factor and various hormones obese women. DESIGN: Case-control study. SETTING: outpatient's Service for the Prevention and Treatment of Obesity at the University Hospital. SUBJECTS: Twenty-five women with mild to moderate obesity, and 15 non-obese healthy women were used as controls. MEASUREMENTS: Evaluation of TGF-β1, insulin, prolactin, sex-hormone binding globulin, androstenedione, free triiodothyronine, free tetraiodothyronine, thyroid-stimulating hormone, dehydroepiandrosterone-sulfate, testosterone, insulin-like growth factor 1, cortisol and adrenocorticotropic hormone plasma concentrations in obese women. Blood samples were taken from fasting subjects for the determination of the above parameters. RESULTS: In obese women plasma TGF-β1 concentrations were lower than in controls. The obsese subjects also had lower GH, IGF-1 and SHBG plasma concentrations and increased insulinaemia. A positive correlation was found between TGF-β1 and both IGF-1 (r = 0.52; P <0.01) and DHEA-S (r = 0.43; P <0.05), while a negative correlation was found between TGF-β1 and SHBG (r = -0.49; P <0.05). CONCLUSIONS: The reduction in TGF-β1, an antilipogenic factor, may play a role in the pathogenesis of obesity and could be involved in the development of some obesity-related endocrine alterations.

Original languageEnglish
Pages (from-to)704-707
Number of pages4
JournalInternational Journal of Obesity
Volume21
Issue number8
Publication statusPublished - 1997

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Keywords

  • Growth factors
  • Hormones
  • Obesity
  • Transforming growth factor β

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Corica, F., Allegra, A., Buemi, M., Corsonello, A., Bonanzinga, S., Rubino, F., Castagna, L., & Ceruso, D. (1997). Reduced plasma concectrations of transforming growth factor β1 (TGF-β1) in obese women. International Journal of Obesity, 21(8), 704-707.