Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: Relationship with neuro-degeneration

Massimiliano M. Corsi, Federico Licastro, Elisa Porcellini, Giada Dogliotti, Emanuela Galliera, John L. Lamont, Paul J. Innocenzi, Stephen P. Fitzgerald

Research output: Contribution to journalArticlepeer-review

Abstract

Neurodegenerative processes associated with Alzheimer's disease (AD) are accompanied by reactive astrogliosis and microglia activation and a role for chronic inflammation in the brain degeneration of these patients has been suggested. Moreover impaired immune functions in AD brains might also influence the disease's progression. Therefore, it is of interest to further characterized inflammatory molecules in the peripheral blood of patients with AD and its relationship with cognitive decline. A complex picture emerged in this pilot study and IL-8, IFNgamma, MCP-1 and VEGF levels were increased in AD. Levels of P-selectin and L-selectin were decreased in AD and lowest in AD patients with highest cognitive decline. Our findings suggest that these molecules may induce alterations of endothelial regulation and influence neurodegenerative processes of AD.

Original languageEnglish
Pages (from-to)451-454
Number of pages4
JournalBiogerontology
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Alzheimer's disease diagnosis and prognosis
  • Fast cognitive decline
  • L-selectin
  • P-selectin
  • Slow cognitive decline

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing

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