Reduced plasma levels of tyrosine, precursor of brain catecholamines, and of essential amino acids in patients with severe traumatic brain injury after rehabilitation

Roberto Aquilani, Paolo Iadarola, Federica Boschi, Caterina Pistarini, Patrizia Arcidiaco, Antonella Contardi

Research output: Contribution to journalArticle

Abstract

Objective: To investigate whether levels of plasma tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, and other essential amino acids (EAA) may return to normal in patients with severe traumatic brain injury (TBI) after 2 months in a hospital rehabilitation center. Design: Peripheral plasma concentrations of tyrosine, tryptophan, and other EAAs in subjects with severe TBI, both at admission (44 ± 11d postinjury) and at discharge from the center (110 ± 15d after acute event) were compared with concentrations in control subjects. Setting: Tertiary care rehabilitation setting in Italy. Participants: Ten men (26.6 ± 12.6y) with TBI and 6 healthy subjects (controls) matched for age, sex, voluntary loss of body weight, and sedentary lifestyle. Interventions: Not applicable. Main Outcome Measures: Concentrations of brain neurotransmitter precursor amino acids and of EAA. Results: On admission, patients had lower plasma tyrosine, leucine, valine, methionine, and phenylalanine concentrations than did control subjects. The plasma concentrations of tryptophan were similar in the 2 groups. These amino acid abnormalities were still present at discharge. Conclusion: The levels of plasma tyrosine and many EAA in patients with TBI did not recover by discharge (110 ± 15d) from rehabilitation. Plasma tryptophan concentrations were similar in patients and controls.

Original languageEnglish
Pages (from-to)1258-1265
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Volume84
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Essential Amino Acids
Catecholamines
Tyrosine
Rehabilitation
Tryptophan
Brain
Neurotransmitter Agents
Sedentary Lifestyle
Amino Acids
Rehabilitation Centers
Patient Admission
Valine
Tertiary Healthcare
Phenylalanine
Leucine
Methionine
Italy
Traumatic Brain Injury
Serotonin
Healthy Volunteers

Keywords

  • Amino acids
  • Head injuries
  • Neurotransmitters
  • Plasmas
  • Rehabilitation

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Reduced plasma levels of tyrosine, precursor of brain catecholamines, and of essential amino acids in patients with severe traumatic brain injury after rehabilitation. / Aquilani, Roberto; Iadarola, Paolo; Boschi, Federica; Pistarini, Caterina; Arcidiaco, Patrizia; Contardi, Antonella.

In: Archives of Physical Medicine and Rehabilitation, Vol. 84, No. 9, 01.09.2003, p. 1258-1265.

Research output: Contribution to journalArticle

@article{775d584d4ef1445ea68fd15ddc339501,
title = "Reduced plasma levels of tyrosine, precursor of brain catecholamines, and of essential amino acids in patients with severe traumatic brain injury after rehabilitation",
abstract = "Objective: To investigate whether levels of plasma tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, and other essential amino acids (EAA) may return to normal in patients with severe traumatic brain injury (TBI) after 2 months in a hospital rehabilitation center. Design: Peripheral plasma concentrations of tyrosine, tryptophan, and other EAAs in subjects with severe TBI, both at admission (44 ± 11d postinjury) and at discharge from the center (110 ± 15d after acute event) were compared with concentrations in control subjects. Setting: Tertiary care rehabilitation setting in Italy. Participants: Ten men (26.6 ± 12.6y) with TBI and 6 healthy subjects (controls) matched for age, sex, voluntary loss of body weight, and sedentary lifestyle. Interventions: Not applicable. Main Outcome Measures: Concentrations of brain neurotransmitter precursor amino acids and of EAA. Results: On admission, patients had lower plasma tyrosine, leucine, valine, methionine, and phenylalanine concentrations than did control subjects. The plasma concentrations of tryptophan were similar in the 2 groups. These amino acid abnormalities were still present at discharge. Conclusion: The levels of plasma tyrosine and many EAA in patients with TBI did not recover by discharge (110 ± 15d) from rehabilitation. Plasma tryptophan concentrations were similar in patients and controls.",
keywords = "Amino acids, Head injuries, Neurotransmitters, Plasmas, Rehabilitation",
author = "Roberto Aquilani and Paolo Iadarola and Federica Boschi and Caterina Pistarini and Patrizia Arcidiaco and Antonella Contardi",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S0003-9993(03)00148-5",
language = "English",
volume = "84",
pages = "1258--1265",
journal = "Archives of Physical Medicine and Rehabilitation",
issn = "0003-9993",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Reduced plasma levels of tyrosine, precursor of brain catecholamines, and of essential amino acids in patients with severe traumatic brain injury after rehabilitation

AU - Aquilani, Roberto

AU - Iadarola, Paolo

AU - Boschi, Federica

AU - Pistarini, Caterina

AU - Arcidiaco, Patrizia

AU - Contardi, Antonella

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Objective: To investigate whether levels of plasma tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, and other essential amino acids (EAA) may return to normal in patients with severe traumatic brain injury (TBI) after 2 months in a hospital rehabilitation center. Design: Peripheral plasma concentrations of tyrosine, tryptophan, and other EAAs in subjects with severe TBI, both at admission (44 ± 11d postinjury) and at discharge from the center (110 ± 15d after acute event) were compared with concentrations in control subjects. Setting: Tertiary care rehabilitation setting in Italy. Participants: Ten men (26.6 ± 12.6y) with TBI and 6 healthy subjects (controls) matched for age, sex, voluntary loss of body weight, and sedentary lifestyle. Interventions: Not applicable. Main Outcome Measures: Concentrations of brain neurotransmitter precursor amino acids and of EAA. Results: On admission, patients had lower plasma tyrosine, leucine, valine, methionine, and phenylalanine concentrations than did control subjects. The plasma concentrations of tryptophan were similar in the 2 groups. These amino acid abnormalities were still present at discharge. Conclusion: The levels of plasma tyrosine and many EAA in patients with TBI did not recover by discharge (110 ± 15d) from rehabilitation. Plasma tryptophan concentrations were similar in patients and controls.

AB - Objective: To investigate whether levels of plasma tyrosine and tryptophan, precursors of brain catecholamine and serotonin neurotransmitters, respectively, and other essential amino acids (EAA) may return to normal in patients with severe traumatic brain injury (TBI) after 2 months in a hospital rehabilitation center. Design: Peripheral plasma concentrations of tyrosine, tryptophan, and other EAAs in subjects with severe TBI, both at admission (44 ± 11d postinjury) and at discharge from the center (110 ± 15d after acute event) were compared with concentrations in control subjects. Setting: Tertiary care rehabilitation setting in Italy. Participants: Ten men (26.6 ± 12.6y) with TBI and 6 healthy subjects (controls) matched for age, sex, voluntary loss of body weight, and sedentary lifestyle. Interventions: Not applicable. Main Outcome Measures: Concentrations of brain neurotransmitter precursor amino acids and of EAA. Results: On admission, patients had lower plasma tyrosine, leucine, valine, methionine, and phenylalanine concentrations than did control subjects. The plasma concentrations of tryptophan were similar in the 2 groups. These amino acid abnormalities were still present at discharge. Conclusion: The levels of plasma tyrosine and many EAA in patients with TBI did not recover by discharge (110 ± 15d) from rehabilitation. Plasma tryptophan concentrations were similar in patients and controls.

KW - Amino acids

KW - Head injuries

KW - Neurotransmitters

KW - Plasmas

KW - Rehabilitation

UR - http://www.scopus.com/inward/record.url?scp=0042337411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042337411&partnerID=8YFLogxK

U2 - 10.1016/S0003-9993(03)00148-5

DO - 10.1016/S0003-9993(03)00148-5

M3 - Article

C2 - 13680559

AN - SCOPUS:0042337411

VL - 84

SP - 1258

EP - 1265

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

SN - 0003-9993

IS - 9

ER -