Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy

R. Michelucci, G. Cipolla, D. Passarelli, G. Gatti, M. Ochan, R. Heinig, C. A. Tassinari, E. Perucca

Research output: Contribution to journalArticle

Abstract

Purpose: To assess whether phenytoin affects the pharmacokinetics of the dihydropyridine calcium antagonist nisoldipine. Methods: Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively). Blood samples were collected for up to 48 h for estimation of plasma nisoldipine levels by capillary gas chromatography. Results: Mean plasma nisoldipine concentrations were much lower in the patients. Geometric means for areas under the concentration-time curve (AUC(0-tn) normalized to a 20-mg dose were 1.6 μg/L/h (95% confidence intervals, 0.6-3.8 μg/L/h) in the patients compared with 15.2 (10.7-21.6) μg/L/h in control subjects (p

Original languageEnglish
Pages (from-to)1107-1110
Number of pages4
JournalEpilepsia
Volume37
Issue number11
Publication statusPublished - 1996

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Nisoldipine
Phenytoin
Epilepsy
Gas Chromatography
Area Under Curve
Healthy Volunteers
Pharmacokinetics
Confidence Intervals
Calcium

Keywords

  • Drug interaction
  • Epilepsy
  • Nisoldipine
  • Pharmacokinetics
  • Phenytoin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Michelucci, R., Cipolla, G., Passarelli, D., Gatti, G., Ochan, M., Heinig, R., ... Perucca, E. (1996). Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy. Epilepsia, 37(11), 1107-1110.

Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy. / Michelucci, R.; Cipolla, G.; Passarelli, D.; Gatti, G.; Ochan, M.; Heinig, R.; Tassinari, C. A.; Perucca, E.

In: Epilepsia, Vol. 37, No. 11, 1996, p. 1107-1110.

Research output: Contribution to journalArticle

Michelucci, R, Cipolla, G, Passarelli, D, Gatti, G, Ochan, M, Heinig, R, Tassinari, CA & Perucca, E 1996, 'Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy', Epilepsia, vol. 37, no. 11, pp. 1107-1110.
Michelucci R, Cipolla G, Passarelli D, Gatti G, Ochan M, Heinig R et al. Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy. Epilepsia. 1996;37(11):1107-1110.
Michelucci, R. ; Cipolla, G. ; Passarelli, D. ; Gatti, G. ; Ochan, M. ; Heinig, R. ; Tassinari, C. A. ; Perucca, E. / Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy. In: Epilepsia. 1996 ; Vol. 37, No. 11. pp. 1107-1110.
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