Reduced plasma nisoldipine concentrations phenytoin-treated patients with epilepsy

R. Michelucci, G. Cipolla, D. Passarelli, G. Gatti, M. Ochan, R. Heinig, C. A. Tassinari, E. Perucca

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess whether phenytoin affects the pharmacokinetics of the dihydropyridine calcium antagonist nisoldipine. Methods: Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively). Blood samples were collected for up to 48 h for estimation of plasma nisoldipine levels by capillary gas chromatography. Results: Mean plasma nisoldipine concentrations were much lower in the patients. Geometric means for areas under the concentration-time curve (AUC(0-tn) normalized to a 20-mg dose were 1.6 μg/L/h (95% confidence intervals, 0.6-3.8 μg/L/h) in the patients compared with 15.2 (10.7-21.6) μg/L/h in control subjects (p

Original languageEnglish
Pages (from-to)1107-1110
Number of pages4
JournalEpilepsia
Volume37
Issue number11
Publication statusPublished - 1996

Keywords

  • Drug interaction
  • Epilepsy
  • Nisoldipine
  • Pharmacokinetics
  • Phenytoin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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