Abstract
Purpose: To assess whether phenytoin affects the pharmacokinetics of the dihydropyridine calcium antagonist nisoldipine. Methods: Twelve patients with epilepsy receiving chronic phenytoin therapy and 12 healthy control subjects matched for age and gender received a single oral dose of nisoldipine (40 and 20 mg, respectively). Blood samples were collected for up to 48 h for estimation of plasma nisoldipine levels by capillary gas chromatography. Results: Mean plasma nisoldipine concentrations were much lower in the patients. Geometric means for areas under the concentration-time curve (AUC(0-tn) normalized to a 20-mg dose were 1.6 μg/L/h (95% confidence intervals, 0.6-3.8 μg/L/h) in the patients compared with 15.2 (10.7-21.6) μg/L/h in control subjects (p
| Original language | English |
|---|---|
| Pages (from-to) | 1107-1110 |
| Number of pages | 4 |
| Journal | Epilepsia |
| Volume | 37 |
| Issue number | 11 |
| Publication status | Published - 1996 |
Keywords
- Drug interaction
- Epilepsy
- Nisoldipine
- Pharmacokinetics
- Phenytoin
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)