Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy

M. Coluzzi, M. L. Calabrò, D. Manno, L. Chieco-Bianchi, T. F. Schulz, V. Ascoli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In two formerly malarious parts of Italy, age-related seroprevalence rates of Kaposi's sarcoma-associated herpesvirus [human herpesvirus 8 (KSHV/ HHV8)] were determined from local blood donors and correlated with periods of vector control during anti-malaria campaigns. In Veneto, decreased KSHV/ HHV8 seroprevalence in the 1951-1955 birth cohort coincides with the peak of DDT house-spraying. In Sardinia, where larviciding augmented indoor DDT-spraying, a significant drop of KSHV/HHV8 seroprevalence between 1945 and 1950 and 1951-1955 birth cohorts (P = 0.0046) coincides with suppression of the malaria vector Anopheles labranchiae Falleroni (Diptera: Culicidae). These results are consistent with age-related association between KSHV/HHV8 seroprevalence rates in native/resident populations and the density of malaria vectors in Veneto and Sardinia. This example supports our 'promoter arthropod' hypothesis on the role of haematophagous insects [putatively blackflies (Simuliidae), sandflies (Phlebotominae) and biting midges (Ceratopogonidae), as well as mosquitoes] when their bites induce hypersensitivity and immunosuppression, potentiate KSHV/HHV8 transmission via human saliva (when insect bite lesions are licked by another person whose saliva carries the virus) and may facilitate Kaposi's sarcoma.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalMedical and Veterinary Entomology
Volume17
Issue number4
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Human herpesvirus 8
Human Herpesvirus 8
Anopheles
malaria
Seroepidemiologic Studies
seroprevalence
Italy
saliva
DDT
insect
resident population
mosquito
lesion
arthropod
Ceratopogonidae
Simuliidae
virus
Malaria
Psychodidae
blood

Keywords

  • Anopheles labranchiae
  • Anti-malaria campaign
  • Arthropod bites
  • Birth cohort
  • Blood donors
  • Blood-sucking insects
  • DDT
  • Haematophagy
  • Human herpesvirus 8
  • Italy
  • Kaposi's sarcoma-associated herpesvirus
  • Malaria
  • Mosquitoes
  • Saliva
  • Seroprevalence
  • Vector control

ASJC Scopus subject areas

  • Insect Science
  • veterinary(all)

Cite this

Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy. / Coluzzi, M.; Calabrò, M. L.; Manno, D.; Chieco-Bianchi, L.; Schulz, T. F.; Ascoli, V.

In: Medical and Veterinary Entomology, Vol. 17, No. 4, 12.2003, p. 461-464.

Research output: Contribution to journalArticle

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abstract = "In two formerly malarious parts of Italy, age-related seroprevalence rates of Kaposi's sarcoma-associated herpesvirus [human herpesvirus 8 (KSHV/ HHV8)] were determined from local blood donors and correlated with periods of vector control during anti-malaria campaigns. In Veneto, decreased KSHV/ HHV8 seroprevalence in the 1951-1955 birth cohort coincides with the peak of DDT house-spraying. In Sardinia, where larviciding augmented indoor DDT-spraying, a significant drop of KSHV/HHV8 seroprevalence between 1945 and 1950 and 1951-1955 birth cohorts (P = 0.0046) coincides with suppression of the malaria vector Anopheles labranchiae Falleroni (Diptera: Culicidae). These results are consistent with age-related association between KSHV/HHV8 seroprevalence rates in native/resident populations and the density of malaria vectors in Veneto and Sardinia. This example supports our 'promoter arthropod' hypothesis on the role of haematophagous insects [putatively blackflies (Simuliidae), sandflies (Phlebotominae) and biting midges (Ceratopogonidae), as well as mosquitoes] when their bites induce hypersensitivity and immunosuppression, potentiate KSHV/HHV8 transmission via human saliva (when insect bite lesions are licked by another person whose saliva carries the virus) and may facilitate Kaposi's sarcoma.",
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AU - Schulz, T. F.

AU - Ascoli, V.

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