Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism

Andrea Varrone, Elena Salvatore, Giuseppe De Michele, Paolo Barone, Valeria Sansone, Maria Teresa Pellecchia, Imma Castaldo, Giovanni Coppola, Arturo Brunetti, Marco Salvatore, Sabina Pappatà, Alessandro Filla

Research output: Contribution to journalArticle

Abstract

Degeneration of substantia nigra has been described in spinocerebellar ataxia type 2 (SCA2). In this study, dopamine transporter (DAT) density with [123I]FP-CIT SPECT was studied in six SCA2 patients with no parkinsonian signs, six Parkinson's disease (PD) patients, and six controls. Marked striatal DAT loss was found in both SCA2 and PD patients. However, a more severe reduction in the caudate and a higher putamen to caudate ratio distinguished SCA2 from PD patients, suggesting a more uniform nigrostriatal impairment in SCA2. Striatal DAT density of SCA2 patients correlated with the severity of cerebellar ataxia.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalAnnals of Neurology
Volume55
Issue number3
DOIs
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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    Varrone, A., Salvatore, E., De Michele, G., Barone, P., Sansone, V., Pellecchia, M. T., Castaldo, I., Coppola, G., Brunetti, A., Salvatore, M., Pappatà, S., & Filla, A. (2004). Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism. Annals of Neurology, 55(3), 426-430. https://doi.org/10.1002/ana.20054