Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

L. Annunziato, D. Cocchi, G. di Renzo, G. L. Rossi, S. Amoroso, M. Taglialatela, E. E. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.

Original languageEnglish
Pages (from-to)425-427
Number of pages3
JournalExperientia
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 1986

Keywords

  • estrogen-treated rats
  • prolactin
  • prolactin secreting adenoma
  • Tuberoinfundibular dopaminergic system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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