Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.
- estrogen-treated rats
- prolactin secreting adenoma
- Tuberoinfundibular dopaminergic system
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)