Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

L. Annunziato; D. Cocchi; G. di Renzo; G. L. Rossi; S. Amoroso; M. Taglialatela; E. E. Müller

doi:10.1007/BF02118641

Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

L. Annunziato, D. Cocchi, G. di Renzo, G. L. Rossi, S. Amoroso, M. Taglialatela, E. E. Müller

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Abstract

Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K⁺ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.

Original language	English
Pages (from-to)	425-427
Number of pages	3
Journal	Experientia
Volume	42
Issue number	4
DOIs	https://doi.org/10.1007/BF02118641
Publication status	Published - Apr 1986

Keywords

estrogen-treated rats
prolactin
prolactin secreting adenoma
Tuberoinfundibular dopaminergic system

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF02118641

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title = "Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment",

abstract = "Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.",

keywords = "estrogen-treated rats, prolactin, prolactin secreting adenoma, Tuberoinfundibular dopaminergic system",

author = "L. Annunziato and D. Cocchi and {di Renzo}, G. and Rossi, {G. L.} and S. Amoroso and M. Taglialatela and M{\"u}ller, {E. E.}",

year = "1986",

month = apr,

doi = "10.1007/BF02118641",

language = "English",

volume = "42",

pages = "425--427",

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T1 - Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

AU - Annunziato, L.

AU - Cocchi, D.

AU - di Renzo, G.

AU - Rossi, G. L.

AU - Amoroso, S.

AU - Taglialatela, M.

AU - Müller, E. E.

PY - 1986/4

Y1 - 1986/4

N2 - Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.

AB - Hypothalamic fragments from female rats treated repeatedly with estradiol valerate (EV) and bearing prolactin (PRL)-secreting tumors contained, seven months after the last EV injection, lower concentrations of dopamine (DA) than age-matched controls. Depolarizing concentrations of K+ (35 mM) and amphetamine (50 μM) evoked in PRL-secreting tumor bearing rats an endogenous DA release significantly lower than in controls.

KW - estrogen-treated rats

KW - prolactin

KW - prolactin secreting adenoma

KW - Tuberoinfundibular dopaminergic system

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Reduced tuberoinfundibular dopaminergic neuronal function in rats after long-term withdrawal of estrogen treatment

Abstract

Keywords

ASJC Scopus subject areas

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