Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia

G. Remuzzi, D. Marchesi, C. Zoja, D. Muratore, G. Mecca, R. Misiani, E. Rossi, M. Barbato, P. Capetta, M. B. Donati, G. de Gaetano

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Abstract

Prostacyclin production was significantly depressed in foetal and placental vascular tissues from five patients with severe pre-eclampsia in comparison to vascular tissues from women with uncomplicated pregnancy. Such an abnormality may be responsible for a reduced blood flow and defective fetal nutrition thus playing a major role in the pathogenesis of this syndrome.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalProstaglandins
Volume20
Issue number1
DOIs
Publication statusPublished - 1980

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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