Reducing socio-economic inequalities in all-cause mortality: a counterfactual mediation approach. International journal of epidemiology

Jessica E. Laine, Valéria T. Baltar, Silvia Stringhini, Martina Gandini, Marc Chadeau-Hyam, Mika Kivimaki, Gianluca Severi, Vittorio Perduca, Allison M. Hodge, Pierre-Antoine Dugué, Graham G. Giles, Roger L. Milne, Henrique Barros, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Marcel Goldberg, Marie Zins, Cyrille DelpierrePaolo Vineis

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Socio-economic inequalities in mortality are well established, yet the contribution of intermediate risk factors that may underlie these relationships remains unclear. We evaluated the role of multiple modifiable intermediate risk factors underlying socio-economic-associated mortality and quantified the potential impact of reducing early all-cause mortality by hypothetically altering socio-economic risk factors. METHODS: Data were from seven cohort studies participating in the LIFEPATH Consortium (total n = 179 090). Using both socio-economic position (SEP) (based on occupation) and education, we estimated the natural direct effect on all-cause mortality and the natural indirect effect via the joint mediating role of smoking, alcohol intake, dietary patterns, physical activity, body mass index, hypertension, diabetes and coronary artery disease. Hazard ratios (HRs) were estimated, using counterfactual natural effect models under different hypothetical actions of either lower or higher SEP or education. RESULTS: Lower SEP and education were associated with an increase in all-cause mortality within an average follow-up time of 17.5 years. Mortality was reduced via modelled hypothetical actions of increasing SEP or education. Through higher education, the HR was 0.85 [95% confidence interval (CI) 0.84, 0.86] for women and 0.71 (95% CI 0.70, 0.74) for men, compared with lower education. In addition, 34% and 38% of the effect was jointly mediated for women and men, respectively. The benefits from altering SEP were slightly more modest. CONCLUSIONS: These observational findings support policies to reduce mortality both through improving socio-economic circumstances and increasing education, and by altering intermediaries, such as lifestyle behaviours and morbidities.
Original languageEnglish
Pages (from-to)497-510
Number of pages14
JournalInternational Journal of Epidemiology
Issue number2
Publication statusPublished - 2020


  • *all-cause mortality
  • *causal inference
  • *health behaviours
  • *intervention
  • *mediation
  • *multiple mediators
  • *Socio-economic inequalities


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