Reduction in phenytoin clearance caused by cimetidine

G. M. Frigo, S. Lecchini, M. Caravaggi, G. Gatti, M. Tonini, L. D'Angelo, E. Perucca, A. Crema

Research output: Contribution to journalArticlepeer-review


The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.

Original languageEnglish
Pages (from-to)135-137
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Issue number1
Publication statusPublished - Jan 1983


  • cimetidine
  • disposition kinetics
  • drug interactions
  • inhibition of metabolism
  • mixed function oxidases
  • phenytoin

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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