Reduction in phenytoin clearance caused by cimetidine

G. M. Frigo; S. Lecchini; M. Caravaggi; G. Gatti; M. Tonini; L. D'Angelo; E. Perucca; A. Crema

doi:10.1007/BF00544030

Reduction in phenytoin clearance caused by cimetidine

G. M. Frigo, S. Lecchini, M. Caravaggi, G. Gatti, M. Tonini, L. D'Angelo, E. Perucca, A. Crema

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.

Original language	English
Pages (from-to)	135-137
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/BF00544030
Publication status	Published - Jan 1983

Keywords

cimetidine
disposition kinetics
drug interactions
inhibition of metabolism
mixed function oxidases
phenytoin

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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10.1007/BF00544030

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abstract = "The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.",

keywords = "cimetidine, disposition kinetics, drug interactions, inhibition of metabolism, mixed function oxidases, phenytoin",

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T1 - Reduction in phenytoin clearance caused by cimetidine

AU - Frigo, G. M.

AU - Lecchini, S.

AU - Caravaggi, M.

AU - Gatti, G.

AU - Tonini, M.

AU - D'Angelo, L.

AU - Perucca, E.

AU - Crema, A.

PY - 1983/1

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N2 - The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.

AB - The effect of cimetidine on the disposition kinetics of phenytoin was investigated in 7 healthy volunteers. Each subject received a single intravenous dose of phenytoin on two occasions, in the control state, and during concurrent treatment with cimetidine 1200 mg/day for 6 days. A slight but statistically significant decrease both in the rate of elimination and total body clearance of phenytoin was observed during the administration of cimetidine. The effect is probably due to inhibition of metabolism.

KW - cimetidine

KW - disposition kinetics

KW - drug interactions

KW - inhibition of metabolism

KW - mixed function oxidases

KW - phenytoin

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Reduction in phenytoin clearance caused by cimetidine

Abstract

Keywords

ASJC Scopus subject areas

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