Abstract
The effect of cyclophosphamide (CY) on precursors of cytotoxic T lymphocytes (CTL), specific for Moloney-murine leukemia virus (M-MuLV)- induced antigens, and on the precursors of cells having natural killer (NK)-like activity was studied by means of limiting dilution assay. Pre-treatment with a single CY dose of 100 mg/kg induced a marked reduction not only in the total spleen cell number but also in the frequencies of M-MuLV-specific CTL, and NK-like cell precursors. Maximal effect was obtained 2 days after CY injection, and a gradual recovery in both total spleen cell number and cytotoxic activity was achieved by day 12. These results confirm that CY exerts a strong but transient immunodepressive effect.
| Original language | English |
|---|---|
| Pages (from-to) | 529-534 |
| Number of pages | 6 |
| Journal | International Journal of Immunopharmacology |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1984 |
ASJC Scopus subject areas
- Immunology
- Pharmacology
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Collavo, D., Ronchese, F., Zanovello, P., Cerundolo, V., & Biasi, G. (1984). Reduction in precursors of cytotoxic T lymphocytes and of cells with natural killer-like activity in spleens of cyclophosphamide-treated mice. International Journal of Immunopharmacology, 6(5), 529-534. https://doi.org/10.1016/0192-0561(84)90092-4