Reduction of bone density: An effect of gonadotropin releasing hormone analogue treatment in central precocious puberty

G. Saggese, S. Bertelloni, G. I. Baroncelli, R. Battini, G. Franchi

Research output: Contribution to journalArticlepeer-review

Abstract

Gonadal steroids drive the significant bone mineral increase that occurs at puberty. Oestrogen deprivation in women results in bone loss. We investigated bone mineralization by single photon absorptiometry in girls with central precocious puberty (n=13, age 3.8-8.5 years) before and during 1 year of treatment with gonadotropin releasing hormone analogue (GnRH-a=longacting D-Trp6-GnRH, 60 μg i.m. every 28 days). Before GnRH-a therapy, bone mineral density (BMD) was significantly higher in patients than in ten control girls matched for chronological age (patients 0.575±0.097 g/cm2, controls 0.433±0.049 g/cm2, P2, P=NS). During GnRH-a treatment, pituitary-gonadal axis was suppressed and patient BMD significantly decreased (6 months: -6.0%, P

Original languageEnglish
Pages (from-to)717-720
Number of pages4
JournalEuropean Journal of Pediatrics
Volume152
Issue number9
DOIs
Publication statusPublished - Sep 1993

Keywords

  • Bone mineral density
  • Bone mineralization
  • Central precocious puberty
  • Gonadotropin-releasing hormone analogue

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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