Abstract
Gonadal steroids drive the significant bone mineral increase that occurs at puberty. Oestrogen deprivation in women results in bone loss. We investigated bone mineralization by single photon absorptiometry in girls with central precocious puberty (n=13, age 3.8-8.5 years) before and during 1 year of treatment with gonadotropin releasing hormone analogue (GnRH-a=longacting D-Trp6-GnRH, 60 μg i.m. every 28 days). Before GnRH-a therapy, bone mineral density (BMD) was significantly higher in patients than in ten control girls matched for chronological age (patients 0.575±0.097 g/cm2, controls 0.433±0.049 g/cm2, P2, P=NS). During GnRH-a treatment, pituitary-gonadal axis was suppressed and patient BMD significantly decreased (6 months: -6.0%, P
Original language | English |
---|---|
Pages (from-to) | 717-720 |
Number of pages | 4 |
Journal | European Journal of Pediatrics |
Volume | 152 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 1993 |
Keywords
- Bone mineral density
- Bone mineralization
- Central precocious puberty
- Gonadotropin-releasing hormone analogue
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health