TY - JOUR
T1 - Reduction of bone density
T2 - An effect of gonadotropin releasing hormone analogue treatment in central precocious puberty
AU - Saggese, G.
AU - Bertelloni, S.
AU - Baroncelli, G. I.
AU - Battini, R.
AU - Franchi, G.
PY - 1993/9
Y1 - 1993/9
N2 - Gonadal steroids drive the significant bone mineral increase that occurs at puberty. Oestrogen deprivation in women results in bone loss. We investigated bone mineralization by single photon absorptiometry in girls with central precocious puberty (n=13, age 3.8-8.5 years) before and during 1 year of treatment with gonadotropin releasing hormone analogue (GnRH-a=longacting D-Trp6-GnRH, 60 μg i.m. every 28 days). Before GnRH-a therapy, bone mineral density (BMD) was significantly higher in patients than in ten control girls matched for chronological age (patients 0.575±0.097 g/cm2, controls 0.433±0.049 g/cm2, P2, P=NS). During GnRH-a treatment, pituitary-gonadal axis was suppressed and patient BMD significantly decreased (6 months: -6.0%, P
AB - Gonadal steroids drive the significant bone mineral increase that occurs at puberty. Oestrogen deprivation in women results in bone loss. We investigated bone mineralization by single photon absorptiometry in girls with central precocious puberty (n=13, age 3.8-8.5 years) before and during 1 year of treatment with gonadotropin releasing hormone analogue (GnRH-a=longacting D-Trp6-GnRH, 60 μg i.m. every 28 days). Before GnRH-a therapy, bone mineral density (BMD) was significantly higher in patients than in ten control girls matched for chronological age (patients 0.575±0.097 g/cm2, controls 0.433±0.049 g/cm2, P2, P=NS). During GnRH-a treatment, pituitary-gonadal axis was suppressed and patient BMD significantly decreased (6 months: -6.0%, P
KW - Bone mineral density
KW - Bone mineralization
KW - Central precocious puberty
KW - Gonadotropin-releasing hormone analogue
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U2 - 10.1007/BF01953983
DO - 10.1007/BF01953983
M3 - Article
C2 - 8223799
AN - SCOPUS:0027321619
VL - 152
SP - 717
EP - 720
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 9
ER -