Reduction of cerebral blood flow in subclinical hepatic encephalopathy and its correlation with plasma-free tryptophan

G. Rodriguez, R. Testa, G. Celle, A. Gris, S. Marenco, F. Nobili, G. Novellone, G. Rosadini

Research output: Contribution to journalArticle

Abstract

Cerebral blood flow (CBF), measured by the noninvasive xenon-133 inhalation method, EEG, and plasma levels of ammonia (NH 3) and free trytophan were determined in 18 hospitalized cirrhotic patients affected with subclinical hepatic encephalopathy, as diagnosed by the Kurtz test. CBF results were significantly lower (p <0.001) in the patients' group as compared with a sex- and age-matched normal control population, although seven patients had values in the normal range. NH 3 was increased only in six, while free tryptophan was increased in all but two patients. A significant negative correlation (p = 0.02) between CBF and free tryptophan was found, even though it appears to be difficult to interpret. We suggest that CBF impairment in some cirrhotic patients with subclinical hepatic encephalopathy may be related to the systemic metabolic derangement caused by the liver disease; free trytophan could have some implication in producing CBF reduction.

Original languageEnglish
Pages (from-to)768-772
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume7
Issue number6
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)

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    Rodriguez, G., Testa, R., Celle, G., Gris, A., Marenco, S., Nobili, F., Novellone, G., & Rosadini, G. (1987). Reduction of cerebral blood flow in subclinical hepatic encephalopathy and its correlation with plasma-free tryptophan. Journal of Cerebral Blood Flow and Metabolism, 7(6), 768-772.