Reduction of regional cerebral blood flow in subclinical hepatic encephalopathy

G. Rodriguez, R. Testa, G. Rosadini

Research output: Contribution to journalArticlepeer-review

Abstract

The regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method (32 probes; Harshaw Tasc 5 system) in ten patients with hepatic cirrhosis diagnosed by liver biopsy, and with subclinical encephalopathy characterized by minor intellectual derangements detected on psychometric testing (Syndrome Kurz test; Numbers-connection test). Thirty-one healthy subjects, matched for age, comprised the control group. The initial slope index (ISI) of the rCBF measurements was considered. Mean hemispheric flow values were found to be significantly (t-test) reduced in patients compared to normal controls (right hemisphere: 40 ± 6, controls 51 ± 6; left hemisphere: 39 ± 6, controls 50 ± 7). The reduction was observed for the measures of each rCBF probe as well. Despite the limited number of patients, the relevance of the rCBF decrement is indicative of a conceivable role of CBF in the physiopathogenesis of hepatic encephalopathy.

Original languageEnglish
Pages (from-to)763
Number of pages1
JournalIRCS Medical Science
Volume11
Issue number8
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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