TY - JOUR
T1 - Reevaluation of acromegalic patients in long-term remission according to newly proposed consensus criteria for control of disease
AU - Verrua, Elisa
AU - Ferrante, Emanuele
AU - Filopanti, Marcello
AU - Malchiodi, Elena
AU - Sala, Elisa
AU - Giavoli, Claudia
AU - Arosio, Maura
AU - Lania, Andrea Gerardo
AU - Ronchi, Cristina Lucia
AU - Mantovani, Giovanna
AU - Beck-Peccoz, Paolo
AU - Spada, Anna
PY - 2014
Y1 - 2014
N2 - Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management. This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, andcomorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria. At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 [[ampi]]mu;g/L in 11 patients (Group A) and below 0.4 [[ampi]]mu;g/L in 29 patients (Group B); moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only. No differences in other evaluated parameters were found. These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be toolowforthecurrentlyusedGHassay.
AB - Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management. This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, andcomorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria. At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 [[ampi]]mu;g/L in 11 patients (Group A) and below 0.4 [[ampi]]mu;g/L in 29 patients (Group B); moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only. No differences in other evaluated parameters were found. These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be toolowforthecurrentlyusedGHassay.
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U2 - 10.1155/2014/581594
DO - 10.1155/2014/581594
M3 - Article
VL - 2014
SP - 1
EP - 8
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
SN - 1687-8337
ER -