Abstract
A patient with erythroleukemia and heterozygous for the Mediterranean variant of the X-linked enzyme glucose-6-phosphate dehydrogease (G6PD) was studied to determine the number and type of progenitor cells in which the disease arose. G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. Erythroleukemia is established as a clonal disease involving a precursor cell common to the erythroid and myeloid lines. After intensive chemotherapy, restoration of nonmonoclonal hemopoiesis is achieved, as indicated by the reappearance of the mosaic phenotype in hemopoeitic cell populations.
| Original language | English |
|---|---|
| Pages (from-to) | 177-179 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 62 |
| Issue number | 1 |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Hematology
Cite this
Reexpression of normal stem cells in erythroleukemia during remission. / Ferraris, A. M.; Canepa, L.; Mareni, C.; Baule, G.; Meloni, T.; Salvidio, E.; Forteleoni, G.; Gaetani, G. F.
In: Blood, Vol. 62, No. 1, 1983, p. 177-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reexpression of normal stem cells in erythroleukemia during remission
AU - Ferraris, A. M.
AU - Canepa, L.
AU - Mareni, C.
AU - Baule, G.
AU - Meloni, T.
AU - Salvidio, E.
AU - Forteleoni, G.
AU - Gaetani, G. F.
PY - 1983
Y1 - 1983
N2 - A patient with erythroleukemia and heterozygous for the Mediterranean variant of the X-linked enzyme glucose-6-phosphate dehydrogease (G6PD) was studied to determine the number and type of progenitor cells in which the disease arose. G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. Erythroleukemia is established as a clonal disease involving a precursor cell common to the erythroid and myeloid lines. After intensive chemotherapy, restoration of nonmonoclonal hemopoiesis is achieved, as indicated by the reappearance of the mosaic phenotype in hemopoeitic cell populations.
AB - A patient with erythroleukemia and heterozygous for the Mediterranean variant of the X-linked enzyme glucose-6-phosphate dehydrogease (G6PD) was studied to determine the number and type of progenitor cells in which the disease arose. G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. Erythroleukemia is established as a clonal disease involving a precursor cell common to the erythroid and myeloid lines. After intensive chemotherapy, restoration of nonmonoclonal hemopoiesis is achieved, as indicated by the reappearance of the mosaic phenotype in hemopoeitic cell populations.
UR - http://www.scopus.com/inward/record.url?scp=0020621163&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020621163&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 177
EP - 179
JO - Blood
JF - Blood
SN - 0006-4971
IS - 1
ER -