Reexpression of normal stem cells in erythroleukemia during remission

A. M. Ferraris, L. Canepa, C. Mareni, G. Baule, T. Meloni, E. Salvidio, G. Forteleoni, G. F. Gaetani

Research output: Contribution to journalArticlepeer-review


A patient with erythroleukemia and heterozygous for the Mediterranean variant of the X-linked enzyme glucose-6-phosphate dehydrogease (G6PD) was studied to determine the number and type of progenitor cells in which the disease arose. G6PD mosaicism was assessed by the different rate of utilization of 2-deoxy-glucose-6-phosphate (2dG6P) by normal and Mediterranean variants of G6PD. Erythroleukemia is established as a clonal disease involving a precursor cell common to the erythroid and myeloid lines. After intensive chemotherapy, restoration of nonmonoclonal hemopoiesis is achieved, as indicated by the reappearance of the mosaic phenotype in hemopoeitic cell populations.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
Issue number1
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

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