Abstract
Original language | English |
---|---|
Pages (from-to) | 1329-1337 |
Number of pages | 9 |
Journal | Chest |
Volume | 151 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- cardiac output
- exercise
- oxygen consumption
- inert gas
- oxygen
- adult
- aged
- anthropometry
- Article
- cardiopulmonary exercise test
- cohort analysis
- controlled study
- female
- heart disease
- heart function
- heart output
- human
- major clinical study
- male
- priority journal
- prognosis
- rebreathing
- reference value
- adolescent
- exercise test
- middle aged
- normal human
- physiology
- young adult
- Adolescent
- Adult
- Aged
- Cardiac Output
- Exercise
- Exercise Test
- Female
- Healthy Volunteers
- Humans
- Male
- Middle Aged
- Oxygen Consumption
- Reference Values
- Young Adult
Fingerprint
Dive into the research topics of 'Reference Values for Peak Exercise Cardiac Output in Healthy Individuals'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Reference Values for Peak Exercise Cardiac Output in Healthy Individuals. / Agostoni, P.; Vignati, C.; Gentile, P. et al.
In: Chest, Vol. 151, No. 6, 2017, p. 1329-1337.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Reference Values for Peak Exercise Cardiac Output in Healthy Individuals
AU - Agostoni, P.
AU - Vignati, C.
AU - Gentile, P.
AU - Boiti, C.
AU - Farina, S.
AU - Salvioni, E.
AU - Mapelli, M.
AU - Magrì, D.
AU - Paolillo, S.
AU - Corrieri, N.
AU - Sinagra, G.
AU - Cattadori, G.
N1 - Cited By :3 Export Date: 6 March 2018 CODEN: CHETB Correspondence Address: Agostoni, P.; Centro Cardiologico Monzino, IRCCS, University of Milan, via Parea 4, Italy; email: piergiuseppe.agostoni@unimi.it Chemicals/CAS: oxygen, 7782-44-7 References: Lipkin, D.P., Poole-Wilson, P.A., Measurement of cardiac output during exercise by the thermodilution and direct Fick techniques in patients with chronic congestive heart failure (1985) Am J Cardiol, 56 (4), pp. 321-324; Francis, G.S., Hemodynamic and neurohumoral responses to dynamic exercise: normal subjects versus patients with heart disease (1987) Circulation, 76 (6), pp. VI11-VI17; Sullivan, M.J., Knight, J.D., Higginbotham, M.B., Cobb, F.R., Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure: muscle blood flow is reduced with maintenance of arterial perfusion pressure (1989) Circulation, 80 (4), pp. 769-781; Chomsky, D.B., Lang, C.C., Rayos, G.H., Hemodynamic exercise testing: a valuable tool in the selection of cardiac transplantation candidates (1996) Circulation, 94 (12), pp. 3176-3183; Metra, M., Faggiano, P., D'Aloia, A., Use of cardiopulmonary exercise testing with hemodynamic monitoring in the prognostic assessment of ambulatory patients with chronic heart failure (1999) J Am Coll Cardiol, 33 (4), pp. 943-950; Weber, K.T., Janicki, J.S., Cardiopulmonary exercise testing for evaluation of chronic cardiac failure (1985) Am J Cardiol, 55 (2), pp. 22A-31A; Schlosshan, D., Barker, D., Pepper, C., Williams, G., Morley, C., Tan, L.B., CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity (2006) Eur J Heart Fail, 8 (5), pp. 515-521; Balady, G.J., Arena, R., Sietsema, K., Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association (2010) Circulation, 122 (2), pp. 191-225; Welsman, J., Bywater, K., Farr, C., Welford, D., Armstrong, N., Reliability of peak V˙O2 and maximal cardiac output assessed using thoracic bioimpedance in children (2005) Eur J Appl Physiol, 94 (3), pp. 228-234; Moore, R., Sansores, R., Guimond, V., Abboud, R., Evaluation of cardiac output by thoracic electrical bioimpedance during exercise in normal subjects (1992) Chest, 102 (2), pp. 448-455; Nugent, A.M., McParland, J., McEneaney, D.J., Non-invasive measurement of cardiac output by a carbon dioxide rebreathing method at rest and during exercise (1994) Eur Heart J, 15 (3), pp. 361-368; Stringer, W.W., Hansen, J.E., Wasserman, K., Cardiac output estimated noninvasively from oxygen uptake during exercise (1997) J Appl Physiol (1985), 82 (3), pp. 908-912; Cotter, G., Moshkovitz, Y., Kaluski, E., The role of cardiac power and systemic vascular resistance in the pathophysiology and diagnosis of patients with acute congestive heart failure (2003) Eur J Heart Fail, 5 (4), pp. 443-451; Cohen-Solal, A., Tabet, J.Y., Logeart, D., Bourgoin, P., Tokmakova, M., Dahan, M., A non-invasively determined surrogate of cardiac power (“circulatory power”) at peak exercise is a powerful prognostic factor in chronic heart failure (2002) Eur Heart J, 23 (10), pp. 806-814; Higginbotham, M.B., Morris, K.G., Williams, R.S., McHale, P.A., Coleman, R.E., Cobb, F.R., Regulation of stroke volume during submaximal and maximal upright exercise in normal man (1986) Circ Res, 58 (2), pp. 281-291; Granath, A., Jonsson, B., Strandell, T., Circulation in healthy old men, studied by right heart catheterization at rest and during exercise in supine and sitting position (1964) Acta Med Scand, 176, pp. 425-446; Bevegard, S., Holmgren, A., Jonsson, B., Circulatory studies in well trained athletes at rest and during heavy exercise: with special reference to stroke volume and the influence of body position (1963) Acta Physiol Scand, 57, pp. 26-50; Stringer, W.W., Whipp, B.J., Wasserman, K., Porszasz, J., Christenson, P., French, W.J., Non-linear cardiac output dynamics during ramp-incremental cycle ergometry (2005) Eur J Appl Physiol, 93 (5-6), pp. 634-639; Julius, S., Amery, A., Whitlock, L.S., Conway, J., Influence of age on the hemodynamic response to exercise (1967) Circulation, 36 (2), pp. 222-230; Sullivan, M.J., Cobb, F.R., Higginbotham, M.B., Stroke volume increases by similar mechanisms during upright exercise in normal men and women (1991) Am J Cardiol, 67 (16), pp. 1405-1412; Rodeheffer, R.J., Gerstenblith, G., Becker, L.C., Fleg, J.L., Weisfeldt, M.L., Lakatta, E.G., Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate (1984) Circulation, 69 (2), pp. 203-213; Vella, C.A., Robergs, R.A., A review of the stroke volume response to upright exercise in healthy subjects (2005) Br J Sports Med, 39 (4), pp. 190-195; Thadani, U., Parker, J.O., Hemodynamics at rest and during supine and sitting bicycle exercise in normal subjects (1978) Am J Cardiol, 41 (1), pp. 52-59; Hossack, K.F., Bruce, R.A., Maximal cardiac function in sedentary normal men and women: comparison of age-related changes (1982) J Appl Physiol Respir Environ Exerc Physiol, 53 (4), pp. 799-804; Gordon, A., Tyni-Lenne, R., Jansson, E., Jensen-Urstad, M., Kaijser, L., Beneficial effects of exercise training in heart failure patients with low cardiac output response to exercise: a comparison of two training models (1999) J Internal Med, 246 (2), pp. 175-182; Mancini, D., Katz, S., Donchez, L., Aaronson, K., Coupling of hemodynamic measurements with oxygen consumption during exercise does not improve risk stratification in patients with heart failure (1996) Circulation, 94 (10), pp. 2492-2496; Wilson, J.R., Groves, J., Rayos, G., Circulatory status and response to cardiac rehabilitation in patients with heart failure (1996) Circulation, 94 (7), pp. 1567-1572; Higginbotham, M.B., Morris, K.G., Coleman, R.E., Cobb, F.R., Sex-related differences in the normal cardiac response to upright exercise (1984) Circulation, 70 (3), pp. 357-366; Agostoni, P., Cattadori, G., Apostolo, A., Noninvasive measurement of cardiac output during exercise by inert gas rebreathing technique: a new tool for heart failure evaluation (2005) J Am Coll Cardiol, 46 (9), pp. 1779-1781; Goda, A., Lang, C.C., Williams, P., Jones, M., Farr, M.J., Mancini, D.M., Usefulness of non-invasive measurement of cardiac output during sub-maximal exercise to predict outcome in patients with chronic heart failure (2009) Am J Cardiol, 104 (11), pp. 1556-1560; Elkayam, U., Wilson, A.F., Morrison, J., Non-invasive measurement of cardiac output by a single breath constant expiratory technique (1984) Thorax, 39 (2), pp. 107-113; Farina, S., Teruzzi, G., Cattadori, G., Noninvasive cardiac output measurement by inert gas rebreathing in suspected pulmonary hypertension (2014) Am J Cardiol, 113 (3), pp. 546-551; Wasserman, K., Hansen, J.E., Sue, D.Y., Stringer, W.W., Whipp, B.J., Clinical Exercise Testing: Principles of Exercise Testing and Interpretation Including Pathophysiology and Clinical Applications (2005), pp. 138-139. , Lippincott Williams & Wilkins Philadelphia, PA; Ekblom, B., Astrand, P.O., Saltin, B., Stenberg, J., Wallström, B., Effect of training on circulatory response to exercise (1968) J Appl Physiol, 24 (4), pp. 518-528; Grimby, G., Nilsson, N.J., Saltin, B., Cardiac output during submaximal and maximal exercise in active middle-aged athletes (1966) J Appl Physiol, 21 (4), pp. 1150-1156; Astrand, P.O., Cuddy, T.E., Saltin, B., Stenberg, J., Cardiac output during submaximal and maximal work (1964) J Appl Physiol, 19, pp. 268-274; Astrand, P.O., Human physical fitness with special reference to sex and age (1956) Physiol Rev, 36 (3), pp. 307-335; Ridout, S.J., Parker, B.A., Smithmyer, S.L., Gonzales, J.U., Beck, K.C., Proctor, D.N., Age and sex influence the balance between maximal cardiac output and peripheral vascular reserve (2010) J Appl Physiol (1985), 108 (3), pp. 483-489; Bogaard, H.J., Woltjer, H.H., Dekker, B.M., van Keimpema, A.R., Postmus, P.E., de Vries, P.M., Haemodynamic response to exercise in healthy young and elderly subjects (1997) Eur J Appl Physiol Occup Physiol, 75 (5), pp. 435-442; Tomai, F., Ciavolella, M., Gaspardone, A., Peak exercise left ventricular performance in normal subjects and in athletes assessed by first-pass radionuclide angiography (1992) Am J Cardiol, 70 (4), pp. 531-535; Guazzi, M., Adams, V., Conraads, V., EACPR/AHA scientific statement: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations (2012) Circulation, 126 (18), pp. 2261-2274; Agostoni, P., Corra, U., Cattadori, G., Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: a multiparametric approach to heart failure prognosis (2013) Int J Cardiol, 167 (6), pp. 2710-2718; Nielsen, O.W., Hansen, S., Gronlund, J., Precision and accuracy of a noninvasive inert gas washin method for determination of cardiac output in men (1994) J Appl Physiol (1985), 76 (4), pp. 1560-1565; Lang, C.C., Agostoni, P., Mancini, D.M., Prognostic significance and measurement of exercise-derived hemodynamic variables in patients with heart failure (2007) J Cardiac Fail, 13 (8), pp. 672-679
PY - 2017
Y1 - 2017
N2 - Background Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Methods Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙O2). Results We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P < .001) and peak V˙O2 was 95% ± 18% of the maximum predicted value (men, 95% ± 19%; women, 95% ± 18%). Peak V˙O2 and peak Q˙ progressively decreased with age (R2, 0.082; P < .001; and R2, 0.144; P < .001, respectively). The V˙O2-derived formula to measure Q˙ at peak exercise was (4.4 × peak V˙O2) + 4.3 in the overall study cohort, (4.3 × peak V˙O2) + 4.5 in men, and (4.9 × peak V˙O2) + 3.6 in women. Conclusions The simultaneous measurement of Q˙ and V˙O2 at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙O2 values. © 2017 American College of Chest Physicians
AB - Background Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Methods Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙O2). Results We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P < .001) and peak V˙O2 was 95% ± 18% of the maximum predicted value (men, 95% ± 19%; women, 95% ± 18%). Peak V˙O2 and peak Q˙ progressively decreased with age (R2, 0.082; P < .001; and R2, 0.144; P < .001, respectively). The V˙O2-derived formula to measure Q˙ at peak exercise was (4.4 × peak V˙O2) + 4.3 in the overall study cohort, (4.3 × peak V˙O2) + 4.5 in men, and (4.9 × peak V˙O2) + 3.6 in women. Conclusions The simultaneous measurement of Q˙ and V˙O2 at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙O2 values. © 2017 American College of Chest Physicians
KW - cardiac output
KW - exercise
KW - oxygen consumption
KW - inert gas
KW - oxygen
KW - adult
KW - aged
KW - anthropometry
KW - Article
KW - cardiopulmonary exercise test
KW - cohort analysis
KW - controlled study
KW - female
KW - heart disease
KW - heart function
KW - heart output
KW - human
KW - major clinical study
KW - male
KW - priority journal
KW - prognosis
KW - rebreathing
KW - reference value
KW - adolescent
KW - exercise test
KW - middle aged
KW - normal human
KW - physiology
KW - young adult
KW - Adolescent
KW - Adult
KW - Aged
KW - Cardiac Output
KW - Exercise
KW - Exercise Test
KW - Female
KW - Healthy Volunteers
KW - Humans
KW - Male
KW - Middle Aged
KW - Oxygen Consumption
KW - Reference Values
KW - Young Adult
U2 - 10.1016/j.chest.2017.01.009
DO - 10.1016/j.chest.2017.01.009
M3 - Article
VL - 151
SP - 1329
EP - 1337
JO - Chest
JF - Chest
SN - 0012-3692
IS - 6
ER -