Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1329-1337 |
| Number of pages | 9 |
| Journal | Chest |
| Volume | 151 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- cardiac output
- exercise
- oxygen consumption
- inert gas
- oxygen
- adult
- aged
- anthropometry
- Article
- cardiopulmonary exercise test
- cohort analysis
- controlled study
- female
- heart disease
- heart function
- heart output
- human
- major clinical study
- male
- priority journal
- prognosis
- rebreathing
- reference value
- adolescent
- exercise test
- middle aged
- normal human
- physiology
- young adult
- Adolescent
- Adult
- Aged
- Cardiac Output
- Exercise
- Exercise Test
- Female
- Healthy Volunteers
- Humans
- Male
- Middle Aged
- Oxygen Consumption
- Reference Values
- Young Adult
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Reference Values for Peak Exercise Cardiac Output in Healthy Individuals. / Agostoni, P.; Vignati, C.; Gentile, P. et al.
In: Chest, Vol. 151, No. 6, 2017, p. 1329-1337.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Reference Values for Peak Exercise Cardiac Output in Healthy Individuals
AU - Agostoni, P.
AU - Vignati, C.
AU - Gentile, P.
AU - Boiti, C.
AU - Farina, S.
AU - Salvioni, E.
AU - Mapelli, M.
AU - Magrì, D.
AU - Paolillo, S.
AU - Corrieri, N.
AU - Sinagra, G.
AU - Cattadori, G.
N1 - Cited By :3 Export Date: 6 March 2018 CODEN: CHETB Correspondence Address: Agostoni, P.; Centro Cardiologico Monzino, IRCCS, University of Milan, via Parea 4, Italy; email: piergiuseppe.agostoni@unimi.it Chemicals/CAS: oxygen, 7782-44-7 References: Lipkin, D.P., Poole-Wilson, P.A., Measurement of cardiac output during exercise by the thermodilution and direct Fick techniques in patients with chronic congestive heart failure (1985) Am J Cardiol, 56 (4), pp. 321-324; Francis, G.S., Hemodynamic and neurohumoral responses to dynamic exercise: normal subjects versus patients with heart disease (1987) Circulation, 76 (6), pp. VI11-VI17; Sullivan, M.J., Knight, J.D., Higginbotham, M.B., Cobb, F.R., Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure: muscle blood flow is reduced with maintenance of arterial perfusion pressure (1989) Circulation, 80 (4), pp. 769-781; Chomsky, D.B., Lang, C.C., Rayos, G.H., Hemodynamic exercise testing: a valuable tool in the selection of cardiac transplantation candidates (1996) Circulation, 94 (12), pp. 3176-3183; 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Astrand, P.O., Human physical fitness with special reference to sex and age (1956) Physiol Rev, 36 (3), pp. 307-335; Ridout, S.J., Parker, B.A., Smithmyer, S.L., Gonzales, J.U., Beck, K.C., Proctor, D.N., Age and sex influence the balance between maximal cardiac output and peripheral vascular reserve (2010) J Appl Physiol (1985), 108 (3), pp. 483-489; Bogaard, H.J., Woltjer, H.H., Dekker, B.M., van Keimpema, A.R., Postmus, P.E., de Vries, P.M., Haemodynamic response to exercise in healthy young and elderly subjects (1997) Eur J Appl Physiol Occup Physiol, 75 (5), pp. 435-442; Tomai, F., Ciavolella, M., Gaspardone, A., Peak exercise left ventricular performance in normal subjects and in athletes assessed by first-pass radionuclide angiography (1992) Am J Cardiol, 70 (4), pp. 531-535; Guazzi, M., Adams, V., Conraads, V., EACPR/AHA scientific statement: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations (2012) Circulation, 126 (18), pp. 2261-2274; 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PY - 2017
Y1 - 2017
N2 - Background Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Methods Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙O2). Results We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P < .001) and peak V˙O2 was 95% ± 18% of the maximum predicted value (men, 95% ± 19%; women, 95% ± 18%). Peak V˙O2 and peak Q˙ progressively decreased with age (R2, 0.082; P < .001; and R2, 0.144; P < .001, respectively). The V˙O2-derived formula to measure Q˙ at peak exercise was (4.4 × peak V˙O2) + 4.3 in the overall study cohort, (4.3 × peak V˙O2) + 4.5 in men, and (4.9 × peak V˙O2) + 3.6 in women. Conclusions The simultaneous measurement of Q˙ and V˙O2 at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙O2 values. © 2017 American College of Chest Physicians
AB - Background Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Methods Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙O2). Results We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P < .001) and peak V˙O2 was 95% ± 18% of the maximum predicted value (men, 95% ± 19%; women, 95% ± 18%). Peak V˙O2 and peak Q˙ progressively decreased with age (R2, 0.082; P < .001; and R2, 0.144; P < .001, respectively). The V˙O2-derived formula to measure Q˙ at peak exercise was (4.4 × peak V˙O2) + 4.3 in the overall study cohort, (4.3 × peak V˙O2) + 4.5 in men, and (4.9 × peak V˙O2) + 3.6 in women. Conclusions The simultaneous measurement of Q˙ and V˙O2 at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙O2 values. © 2017 American College of Chest Physicians
KW - cardiac output
KW - exercise
KW - oxygen consumption
KW - inert gas
KW - oxygen
KW - adult
KW - aged
KW - anthropometry
KW - Article
KW - cardiopulmonary exercise test
KW - cohort analysis
KW - controlled study
KW - female
KW - heart disease
KW - heart function
KW - heart output
KW - human
KW - major clinical study
KW - male
KW - priority journal
KW - prognosis
KW - rebreathing
KW - reference value
KW - adolescent
KW - exercise test
KW - middle aged
KW - normal human
KW - physiology
KW - young adult
KW - Adolescent
KW - Adult
KW - Aged
KW - Cardiac Output
KW - Exercise
KW - Exercise Test
KW - Female
KW - Healthy Volunteers
KW - Humans
KW - Male
KW - Middle Aged
KW - Oxygen Consumption
KW - Reference Values
KW - Young Adult
U2 - 10.1016/j.chest.2017.01.009
DO - 10.1016/j.chest.2017.01.009
M3 - Article
VL - 151
SP - 1329
EP - 1337
JO - Chest
JF - Chest
SN - 0012-3692
IS - 6
ER -