Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study

Giovanni Donato Aquaro, Giovanni Camastra, Lorenzo Monti, Massimo Lombardi, Alessia Pepe, Silvia Castelletti, Viviana Maestrini, Giancarlo Todiere, Piergiorgio Masci, Gabriella di Giovine, Andrea Barison, Santo Dellegrottaglie, Martina Perazzolo Marra, Gianluca Pontone, Gianluca Di Bella, working group “Applicazioni della Risonanza Magnetica” of the Italian Society of Cardiology

Research output: Contribution to journalArticlepeer-review


PURPOSE: To define reference values of cardiac volumes, dimensions, and new morpho-functional parameters normalized for age, gender, and body surface area by cine-bSSFP (balanced steady-state free-precession) magnetic resonance (MR).

MATERIALS AND METHODS: We enrolled 308 healthy subjects subdivided by gender and by six age classes: class I, >15-20 years; class II, >20-30 years; class III, >30-40 years; class IV, >40-50 years; class V, >50-60 years; and class VI >60 years. Dimensional, volumetric and morpho-functional parameters of the left (LV) and right (RV) ventricles were measured using cine-bSSFP MRI at 1.5T.

RESULTS: The LV and RV end-diastolic volume indexes (EDVi) were inversely related to age (P < 0.0001 r = -0.34 and P < 0.0001 r = -0.37, respectively). In addition, the LV mass index decreased with age (P = 0.0004, r = -0.21). The LV longitudinal shortening was not significantly different among groups: ≥15% in all populations (95% confidence interval [CI]: 16-31). The sphericity index measured in end-diastole was higher in females than in males (P < 0.03): the upper limit was 40% for males and 42% for females. The normality cutoff of LV global function index was ≥33% in males and ≥35% in females. The end-diastolic volume (EDV) of RV and LV was balanced (RV/LV ratio 0.85-1.15) without differences in the population. The LV EDV/mass was 1.0-1.8 in males and 1.0-2.1 in females.

CONCLUSION: This study provides potential age- and gender-specific reference.

LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:1055-1067.

Original languageEnglish
Pages (from-to)1055-1067
Number of pages13
JournalJournal of Magnetic Resonance Imaging
Issue number4
Publication statusPublished - Apr 2017


  • Journal Article

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