Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC

G. Sozzi, M. A. Pierotti, M. Miozzo, R. Donghi, P. Radice, V. De Benedetti, M. Grieco, M. Santoro, A. Fusco, G. Vecchio, C. G P Mathew, B. A J Ponder, N. K. Spurr, G. Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

In this report we confirm the localization of the human RET proto-oncogene to chromosome 10q11.2, both by Southern blot analysis of a panel of human-rodent somatic cell hybrids and by in situ hybridization on human metaphase chromosomes. Previously, we had assigned to the same chromosome region the gene termed H4. In about 25% of papillary thyroid carcinomas, this gene was shown to rearrange with RET to give rise to the transforming sequence PTC. The analysis of different cell hybrids containing subfragments of chromosome 10, in conjunction with pulse field gel electrophoresis, established that H4 is mapped distally to RET at a distance not less than 280 kb. These findings suggest that intrachromosomal rearrangements are responsible for PTC activation in papillary thyroid carcinomas.

Original languageEnglish
Pages (from-to)339-342
Number of pages4
JournalOncogene
Volume6
Issue number2
Publication statusPublished - Feb 1991

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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