Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients

Vlasta Bari, Jose F. Valencia, Montserrat Vallverdu, Giulia Girardengo, Tito Bassani, Andrea Marchi, Laura Calvillo, Pere Caminal, Sergio Cerutti, Paul A. Brink, Lia Crotti, Peter J. Schwartz, Alberto Porta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study assesses complexity of cardiovascular control in patients affected by type-1 variant of long QT (LQT1) syndrome. Complexity was assessed by refined multiscale entropy of heart period (HP) and QT interval variabilities. HP was taken as the time distance between two consecutive R peaks (RR) and QT interval was approximated as the time distance between the R-peak and T-wave apex (RTa) and between R-peak and T-wave end (RTe). RR, RTa and RTe intervals were automatically extracted from 24h Holter recordings and the daytime period was analyzed (from 02-00 to 06:00 PM). Non mutation carrier (NMC) individuals (n=11), utilized as a control group, were taken from the same family line of the mutation carrier (MC) subjects (n=26). We found that, while NMC and MC groups were indistinguishable based on time domain and complexity analyses of RR dynamics, complexity analysis of RTa and RTe variabilities clearly separates the two populations and suggests an impairment in the cardiac control mechanisms acting on the ventricles.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5554-5557
Number of pages4
ISBN (Print)9781457702167
DOIs
Publication statusPublished - 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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    Bari, V., Valencia, J. F., Vallverdu, M., Girardengo, G., Bassani, T., Marchi, A., Calvillo, L., Caminal, P., Cerutti, S., Brink, P. A., Crotti, L., Schwartz, P. J., & Porta, A. (2013). Refined multiscale entropy analysis of heart period and QT interval variabilities in long QT syndrome type-1 patients. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 5554-5557). [6610808] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2013.6610808