Reflectance confocal microscopy assessmentof the depigmenting agents complex formelasma treatment

BACKGROUND: The management of melasma remains a challenge in dermatology, despite the availabilityof a variety of therapies, such as sunscreens, hypopigmented topical treatments, and chemical peels. Theideal treatment for melasma should be efficient, conclusive, and free from side effects.Objective: The aim of this study is to assess the efficacy and tolerability of a depigmenting agent complex,based on the synergy of oligopeptide-68, phytic acid, glycolic acid, lactic acid, and octinoxate measured byclinical and reflectance confocal microscopy outcomes in melasma patients. Methods: Twenty female patients exhibiting clinical evidence of melasma, aged between 29 and 61 years,were randomly enrolled in the study. Reflectance confocal microscopy was performed at baseline and afterthree months of treatment. mostfrequently in women with Fitzpatrick Skin Phototypes 3 through 5. It can be caused or aggravated byprolonged sun exposure and high levels of sex hormones as a result of pregnancy or extensive use of birthcontrol pills. Other risk factors include use of certain drugs, such as tetracycline or antimalarial drugs. Theexcessive pigmentation has been attributed to both the increased number of melanocytes and theproduction of melanin.