Reflectance confocal microscopy for the evaluation of solitary red nodules

Elvira Moscarella, Iris Zalaudek, Marina Agozzino, Hernando Vega, Carlo Cota, Caterina Catricalà, Giuseppe Argenziano, Marco Ardigò

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The correct assessment of a solitary red nodule in clinical practice is of crucial importance, amelanotic melanoma being the most important differential diagnosis. Dermoscopy is nowadays a pivotal tool in the management of skin tumors, however it has some limitations in the evaluation of nonpigmented lesions, in which the diagnosis is merely based on the evaluation of the vascular pattern. Recently, reflectance confocal microscopy has been introduced as a new, noninvasive technique for the diagnosis of skin lesions. Confocal microscopy provides skin imaging in vivo at cellular level resolution, close to conventional histology. We present a series of clinical scenarios of red nodules, including melanoma metastasis, pyogenic granuloma, eccrine poroma, Spitz nevus and dermatofibroma. Reflectance confocal microscopy examination added important information to the clinical diagnosis and subsequent management in all cases except for dermatofibroma. We discuss the advantages and limitations of this technique in this particular field of application.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalDermatology
Volume224
Issue number4
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Confocal Microscopy
Benign Fibrous Histiocytoma
Skin
Poroma
Epithelioid and Spindle Cell Nevus
Amelanotic Melanoma
Pyogenic Granuloma
Dermoscopy
Blood Vessels
Melanoma
Histology
Differential Diagnosis
Neoplasm Metastasis
Neoplasms

Keywords

  • Amelanotic nodular lesions
  • Dermoscopy
  • Reflectance confocal microscopy
  • Skin tumors

ASJC Scopus subject areas

  • Dermatology

Cite this

Moscarella, E., Zalaudek, I., Agozzino, M., Vega, H., Cota, C., Catricalà, C., ... Ardigò, M. (2012). Reflectance confocal microscopy for the evaluation of solitary red nodules. Dermatology, 224(4), 295-300. https://doi.org/10.1159/000339339

Reflectance confocal microscopy for the evaluation of solitary red nodules. / Moscarella, Elvira; Zalaudek, Iris; Agozzino, Marina; Vega, Hernando; Cota, Carlo; Catricalà, Caterina; Argenziano, Giuseppe; Ardigò, Marco.

In: Dermatology, Vol. 224, No. 4, 08.2012, p. 295-300.

Research output: Contribution to journalArticle

Moscarella, E, Zalaudek, I, Agozzino, M, Vega, H, Cota, C, Catricalà, C, Argenziano, G & Ardigò, M 2012, 'Reflectance confocal microscopy for the evaluation of solitary red nodules', Dermatology, vol. 224, no. 4, pp. 295-300. https://doi.org/10.1159/000339339
Moscarella E, Zalaudek I, Agozzino M, Vega H, Cota C, Catricalà C et al. Reflectance confocal microscopy for the evaluation of solitary red nodules. Dermatology. 2012 Aug;224(4):295-300. https://doi.org/10.1159/000339339
Moscarella, Elvira ; Zalaudek, Iris ; Agozzino, Marina ; Vega, Hernando ; Cota, Carlo ; Catricalà, Caterina ; Argenziano, Giuseppe ; Ardigò, Marco. / Reflectance confocal microscopy for the evaluation of solitary red nodules. In: Dermatology. 2012 ; Vol. 224, No. 4. pp. 295-300.
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