Reflex control of circulation in the elderly

G. Mancia, J. Cléroux, A. Daffonchio, A. U. Ferrari, C. Giannattasio, G. Grassi

Research output: Contribution to journalArticlepeer-review


Baroreceptor control of heart rate is markedly reduced in elderly subjects. However, the effects of aging on baroreceptor control of blood pressure and on the vascular and neurohumoral influences of volume cardiopulmonary receptors are unknown. In this paper we report evidence that in both conscious rats and humans aging is associated with a fall in the baroreceptor ability to rapidly cause blood pressure changes, but that the more long-term carotid baroreceptor control of blood pressure remains similar to that observed in younger individuals. Early and late cardiopulmonary receptor modulation of vascular resistance is impaired by aging, which also reduces the influence of this reflex on renin secretion. These dynamic and steady-state alterations in reflex cardiovascular control account for several hemodynamic abnormalities of the advanced age.

Original languageEnglish
Pages (from-to)1223-1228
Number of pages6
JournalCardiovascular Drugs and Therapy
Issue number6 Supplement
Publication statusPublished - Jan 1991


  • aging
  • baroreceptors
  • blood pressure
  • cardiopulmonary receptors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine


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