Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats

V. S. Bishop, F. Lombardi, A. Malliani, M. Pagani, G. Recordati

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

The reflex tachycardia elicited by rapid i.v. infusions of a blood substitute was studied in 21 chronic cats with spinal sections at C 8. All animals could breathe spontaneously. The day after section the average resting heart rate (HR) and arterial pressure (AP) were 109 beats/min and 98/67 mmHg, respectively. Vagal blockade with atropine (0.5-0.7 mg/kg iv) was performed prior to each infusion, increasing the average HR to 127 beats/min. In 39 infusions in 21 cats the average increase in HR was 10 beats/min (range from -6 to +22 beats/min). A tachycardia was observed in all but five trials, four of which were obtained in two cats that subsequently responded with a tachycardia. In seven animals the neural circuit mediating the response was partially or totally interrupted by section of several thoracic dorsal roots (T 1-T 4 or T 1-T 6) and of the spinal cord at the inferior level of these sections (between T 6 and T 7). The tachycardia response was progressively reduced and finally abolished by these procedures. These experiments indicate that spinal neural mechanisms are likely to contribute to the phenomenon first described by Bainbridge.

Original languageEnglish
Title of host publicationAmerican Journal of Physiology
Pages25-29
Number of pages5
Volume230
Edition1
Publication statusPublished - 1976

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Intravenous Infusions
Tachycardia
Reflex
Cats
Heart Rate
Blood Substitutes
Spinal Nerve Roots
Atropine
Spinal Cord
Arterial Pressure
Thorax

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bishop, V. S., Lombardi, F., Malliani, A., Pagani, M., & Recordati, G. (1976). Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats. In American Journal of Physiology (1 ed., Vol. 230, pp. 25-29)

Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats. / Bishop, V. S.; Lombardi, F.; Malliani, A.; Pagani, M.; Recordati, G.

American Journal of Physiology. Vol. 230 1. ed. 1976. p. 25-29.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bishop, VS, Lombardi, F, Malliani, A, Pagani, M & Recordati, G 1976, Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats. in American Journal of Physiology. 1 edn, vol. 230, pp. 25-29.
Bishop VS, Lombardi F, Malliani A, Pagani M, Recordati G. Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats. In American Journal of Physiology. 1 ed. Vol. 230. 1976. p. 25-29
Bishop, V. S. ; Lombardi, F. ; Malliani, A. ; Pagani, M. ; Recordati, G. / Reflex sympathetic tachycardia during intravenous infusions in chronic spinal cats. American Journal of Physiology. Vol. 230 1. ed. 1976. pp. 25-29
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