Reflex vasopressin and renin modulation by cardiac receptors in humans

C. Giannattasio, A. Del Bo, B. M. Cattaneo, C. Cuspidi, E. Gronda, M. Frigerio, M. Mangiavacchi, M. Marabini, C. De Vita, G. Grassi, A. Zanchetti, G. Mancia

Research output: Contribution to journalArticle

Abstract

Animal studies have shown that vasopressin secretion is modulated by arterial baroreceptors and cardiopulmonary volume receptors. Whether this is the case also in humans is controversial, however. To determine whether vasopressin is reflexly modulated by cardiac volume receptors, we studied the effect on plasma vasopressin (venous blood, radioimmunoassay) of reducing venous return and left ventricular end-diastolic diameter (echocardiography) by producing a 20-minute lower body negative pressure in 14 healthy subjects (aged 49.3±3.8 years, mean±SEM). The data were compared with those of 14 age-matched heart-transplant recipients, i.e., subjects with cardiac denervation. In healthy subjects, lower body negative pressure at -15 mm Hg caused a modest reduction in left ventricular end-diastolic diameter (- 5±3.4%) and no change in vasopressin, whereas lower body negative pressure at -37.5 mm Hg caused a more marked reduction in left ventricular end- diastolic diameter (-12±2.5%) and a small, variable, but overall statistically significant (p>0.05) increase in vasopressin (+145±46%, p

Original languageEnglish
Pages (from-to)461-469
Number of pages9
JournalHypertension
Volume21
Issue number4
Publication statusPublished - 1993

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Vasopressins
Renin
Reflex
Lower Body Negative Pressure
Healthy Volunteers
Cardiac Volume
Pressoreceptors
Denervation
Radioimmunoassay
Echocardiography

Keywords

  • antidiuretic hormone
  • baroreceptors
  • cardiac volume
  • cardiopulmonary receptors
  • renin
  • vasopressin

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Giannattasio, C., Del Bo, A., Cattaneo, B. M., Cuspidi, C., Gronda, E., Frigerio, M., ... Mancia, G. (1993). Reflex vasopressin and renin modulation by cardiac receptors in humans. Hypertension, 21(4), 461-469.

Reflex vasopressin and renin modulation by cardiac receptors in humans. / Giannattasio, C.; Del Bo, A.; Cattaneo, B. M.; Cuspidi, C.; Gronda, E.; Frigerio, M.; Mangiavacchi, M.; Marabini, M.; De Vita, C.; Grassi, G.; Zanchetti, A.; Mancia, G.

In: Hypertension, Vol. 21, No. 4, 1993, p. 461-469.

Research output: Contribution to journalArticle

Giannattasio, C, Del Bo, A, Cattaneo, BM, Cuspidi, C, Gronda, E, Frigerio, M, Mangiavacchi, M, Marabini, M, De Vita, C, Grassi, G, Zanchetti, A & Mancia, G 1993, 'Reflex vasopressin and renin modulation by cardiac receptors in humans', Hypertension, vol. 21, no. 4, pp. 461-469.
Giannattasio C, Del Bo A, Cattaneo BM, Cuspidi C, Gronda E, Frigerio M et al. Reflex vasopressin and renin modulation by cardiac receptors in humans. Hypertension. 1993;21(4):461-469.
Giannattasio, C. ; Del Bo, A. ; Cattaneo, B. M. ; Cuspidi, C. ; Gronda, E. ; Frigerio, M. ; Mangiavacchi, M. ; Marabini, M. ; De Vita, C. ; Grassi, G. ; Zanchetti, A. ; Mancia, G. / Reflex vasopressin and renin modulation by cardiac receptors in humans. In: Hypertension. 1993 ; Vol. 21, No. 4. pp. 461-469.
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