Regenerating rat liver: Correlations between estrogen receptor localization and deoxyribonucleic acid synthesis

A. Francavilla, A. Di Leo, P. K. Eagon, S. Q. Wu, P. Ove, D. H. van Thiel, T. E. Starzl

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Abstract

Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after hepatectomy and at 48 h is 30% of that in normal rat liver. Nuclear estrogen binding 48 h after surgery is elevated fivefold over normal values. No alterations in affinity of the receptor for estrogen have been observed. Specificity studies indicate that the estrogen receptors from both normal and regenerating liver were similar and are highly specific for estrogens. These changes in cellular distribution of receptors parallel increases in nuclear deoxyribonucleic acid synthesis and mitotic indices in the liver.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalGastroenterology
Volume86
Issue number3
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Francavilla, A., Di Leo, A., Eagon, P. K., Wu, S. Q., Ove, P., van Thiel, D. H., & Starzl, T. E. (1984). Regenerating rat liver: Correlations between estrogen receptor localization and deoxyribonucleic acid synthesis. Gastroenterology, 86(3), 552-557.