Regeneration and bioengineering of the kidney: Current status and future challenges

Marcus Salvatori, Andrea Peloso, Ravi Katari, Giuseppe Orlando

Research output: Contribution to journalArticle

Abstract

The prevalence of chronic kidney disease continues to outpace the development of effective treatment strategies. For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions. Allogeneic transplantation remains the only restorative treatment, but donor shortage, surgical morbidity and the need for lifelong immunosuppression significantly limit clinical application. Emerging technologies in the fields of regenerative medicine and tissue engineering strive to address these limitations. We review recent advances in cell-based therapies, primordial allografts, bio-artificial organs and whole-organ bioengineering as they apply to renal regeneration. Collaborative efforts across these fields aim to produce a bioengineered kidney capable of restoring renal function in patients with end-stage disease.

Original languageEnglish
Article number379
JournalCurrent Urology Reports
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • ARFAcuteRenalFailure
  • BAKBio-ArtificialKidney
  • BMDCBone Marrow-Derived Stem Cell
  • CKDChronic Kidney Disease
  • DRTDecellularization- Recellularization Technology
  • ECMExtracellularMatrix
  • ESC Embryonic Stem Cell
  • ESRD End-Stage RenalDisease
  • HafscHuman Amniotic Fluid-Derived Stem Cells
  • IPSC Induced Pluripotent Stem Cells
  • MSC Mesenchymal Stem Cell
  • RADRenalTubuleAssisted Device
  • RMRegenerativeMedicine

ASJC Scopus subject areas

  • Urology

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