Regenerative and engineered options for urethroplasty

Filippo Pederzoli, Gregory Joice, Andrea Salonia, Trinity J. Bivalacqua, Nikolai A. Sopko

Research output: Contribution to journalReview articlepeer-review

Abstract

Surgical correction of urethral strictures by substitution urethroplasty — the use of grafts or flaps to correct the urethral narrowing — remains one of the most challenging procedures in urology and is frequently associated with complications, restenosis and poor quality of life for the affected individual. Tissue engineering using different cell types and tissue scaffolds offers a promising alternative for tissue repair and replacement. The past 30 years of tissue engineering has resulted in the development of several therapies that are now in use in the clinic, especially in treating cutaneous, bone and cartilage defects. Advances in tissue engineering for urethral replacement have resulted in several clinical applications that have shown promise but have not yet become the standard of care.

Original languageEnglish
Pages (from-to)453-464
Number of pages12
JournalNature Reviews Urology
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 1 2019

ASJC Scopus subject areas

  • Urology

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