Regenerative application of stromal vascular fraction cells enhanced fat graft maintenance: clinical assessment in face rejuvenation

Pietro Gentile, Aris Sterodimas, Claudio Calabrese, Barbara De Angelis, Angelo Trivisonno, Jacopo Pizzicannella, Laura Dionisi, Domenico De Fazio, Simone Garcovich

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of the use of FG-SVFs in face rejuvenation for esthetic improvement.

METHODS: 33 female patients affected by face's soft-tissue defects with loss of volume, study group (SG), were treated with FG-SVFs, comparing results with a control group (CG) (n = 30) treated with fat graft not enhanced (FG). Clinical evaluation, a photographic assessment, magnetic resonance imaging (MRI), and ultrasound (US) were performed. Post-operative follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually.

RESULTS: SG patients showed 61% maintenance of the contour restoring and of volume after 3 years compared with the CG treated with FG, who showed 31% maintenance. 60.7% (n = 20) of SG patients, presented an increase of 6.6 mm in the soft tissue volume after 36 months, which was reported in only 33,3% (n = 10) of the CG. Volumetric persistence in the SG was higher than that in the CG (p <. 0001 vs. CG). MRI and US moreover confirmed the absence of important side effects, as fat necrosis, and cytosteatonecrotic areas.

CONCLUSIONS: The use of FG-SVFs was safe and effective in this series of a case treated.

Original languageEnglish
Pages (from-to)1503-1513
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 2020

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