Regenerative medicine for the treatment of teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors

Marco Scala, Silvia Lenarduzzi, Francesco Spagnolo, Maria Trapasso, Chiara Ottonello, Anita Muraglia, Annalisa Barla, Paolo Strada

Research output: Contribution to journalArticle

Abstract

Background/Aim: The aim of the present study was to evaluate the safety and the clinical outcome of platelet-rich plasma for the treatment of teno-desmic injures in competition horses. Patients and Methods: From January 2009 to December 2011, 150 sport horses suffering from teno-desmic injuries were treated with no-gelled plateletconcentrate. Results: No horse showed any major adverse reaction as a result of the procedure. Full healing was obtained for 81% of the horses. Twelve percent had clinical improvement and only 7% a failure. Eight percent of cases of relapse were observed. No statistically significant correlation existed between clinical outcome and the area of the lesion. A statistically significant correlation existed between the clinical outcome and the age of the horse. Conclusion: Treatment with platelet-derived growth factors leads to the formation of a tendon with normal morphology and functionality, which translate in the resumption of the agonistic activity for the horses we treated.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalIn Vivo
Volume28
Issue number6
Publication statusPublished - Nov 1 2014

Keywords

  • Platelet
  • Platelet-concentrate
  • Regenerative medicine
  • Regenerative surgery
  • Teno-desmic injuries
  • Tissue regeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Medicine(all)

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    Scala, M., Lenarduzzi, S., Spagnolo, F., Trapasso, M., Ottonello, C., Muraglia, A., Barla, A., & Strada, P. (2014). Regenerative medicine for the treatment of teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors. In Vivo, 28(6), 1119-1124.