Regenerative medicine in Huntington's disease: Strengths and weaknesses of preclinical studies

A. M. Tartaglione, P. Popoli, G. Calamandrei

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder, characterized by impairment in motor, cognitive and psychiatric domains. Currently, there is no specific therapy to act on the onset or progression of HD. The marked neuronal death observed in HD is a main argument in favour of stem cells (SCs) transplantation as a promising therapeutic perspective to replace the population of lost neurons and restore the functionality of the damaged circuitry. The availability of rodent models of HD encourages the investigation of the restorative potential of SCs transplantation longitudinally. However, the results of preclinical studies on SCs therapy in HD are so far largely inconsistent; this hampers the individuation of the more appropriate model and precludes the comparative analysis of transplant efficacy on behavioural end points. Thus, this review will describe the state of the art of in vivo research on SCs therapy in HD, analysing in a translational perspective the strengths and weaknesses of animal studies investigating the therapeutic potential of cell transplantation on HD progression.

Original languageEnglish
Pages (from-to)32-47
Number of pages16
JournalNeuroscience and Biobehavioral Reviews
Volume77
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Regenerative Medicine
Huntington Disease
Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Individuation
Cell Transplantation
Neurodegenerative Diseases
Psychiatry
Disease Progression
Rodentia
Stem Cells
Therapeutics
Transplants
Neurons
Research
Population

Keywords

  • Behavioural analysis
  • Behavioural methods
  • In vivo imaging
  • Neurodegenerative diseases
  • Rodent models
  • Stem cell therapy
  • Transplantation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Regenerative medicine in Huntington's disease : Strengths and weaknesses of preclinical studies. / Tartaglione, A. M.; Popoli, P.; Calamandrei, G.

In: Neuroscience and Biobehavioral Reviews, Vol. 77, 01.06.2017, p. 32-47.

Research output: Contribution to journalReview article

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