Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: A morphological report

O. Trubiani, G. Orsini, N. Zini, D. Di Iorio, M. Piccirilli, A. Piattelli, S. Caputi

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have shown that mesenchymal stem cells obtained from periodontal ligament (PDL-MSCs) are multipotent cells that have similar features of the bone marrow and dental pulp MSCs and are capable of proliferating and producing different types of tissue such as bone and tooth associated-tissues. Human PDL-MSCs expanded ex vivo were induced to osteogenesis, seeded in three-dimensional biocompatible scaffolds (fibrin sponge, bovine-derived substitutes) and examined using light, scanning and transmission electron microscopy. Morphological observations showed extensive growth of cellular biomass partially covering the scaffolds after 4 weeks of incubation in mineralization medium. These findings indicate that periodontal ligament can be an easily and efficient autologous source of stem cells with a high expansion capacity and ability to differentiate in osteogenic cells that can colonize and grow connected to bio-compatible scaffold. It can be suggested that the use of PDL-MSCs for generating graft biomaterials is advantageous for bone tissue engineering in regenerative dentistry.

Original languageEnglish
Pages (from-to)986-993
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume87
Issue number4
DOIs
Publication statusPublished - Dec 15 2008

Keywords

  • Biomaterials
  • Human
  • Mesenchymal stem cells
  • Osteogenesis
  • Periodontium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

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