Regenerative therapies for diabetic microangiopathy

Roberto Bassi, Alessio Trevisani, Sara Tezza, Moufida Ben Nasr, Francesca Gatti, Andrea Vergani, Antonio Farina, Paolo Fiorina

Research output: Contribution to journalArticle

Abstract

Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose homeostasis and insulin/insulin-precursors production, generation of advanced glycation end-products, reduction in nitric oxide synthesis, and oxidative and reductive stress. It occurs both at extracellular level with increased calcium and matrix proteins deposition and at intracellular level, with abnormalities of intracellular pathways and increased cell death. Peripheral arterial disease, coronary heart disease, and ischemic stroke are the main causes of morbidity/mortality in diabetic patients representing a major clinical and economic issue. Pharmacological therapies, administration of growth factors, and stem cellular strategies are the most effective approaches and will be discussed in depth in this comprehensive review covering the regenerative therapies of diabetic microangiopathy.

Original languageEnglish
Article number916560
JournalExperimental Diabetes Research
Volume2012
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Medicine(all)
  • Endocrinology, Diabetes and Metabolism
  • Music

Cite this

Bassi, R., Trevisani, A., Tezza, S., Ben Nasr, M., Gatti, F., Vergani, A., Farina, A., & Fiorina, P. (2012). Regenerative therapies for diabetic microangiopathy. Experimental Diabetes Research, 2012, [916560]. https://doi.org/10.1155/2012/916560