Regenerative therapy in peripheral artery disease

Antonia Germani, Cristiana Di Campli, Giulio Pompilio, Paolo Biglioli, Maurizio C. Capogrossi

Research output: Contribution to journalArticle

Abstract

Patients with peripheral artery disease (PAD) and critical limb ischemia are the main candidates for limb amputations and have a poor life expectancy. Frequently, these patients are not eligible for either surgical or percutaneous interventions aimed at mechanical revascularization. Therefore, new strategies need to be identified to offer these patients a viable therapeutic option. Gene and cell therapy hold great promise for the treatment of peripheral vascular diseases because, in animal models, local delivery of growth factors and endothelial progenitor cells result in new blood vessel formation and regeneration of ischemic tissues. In this article, are reviewed phase I and phase II gene, and cell therapy clinical trials in patients with PAD.

Original languageEnglish
Pages (from-to)289-304
Number of pages16
JournalCardiovascular Therapeutics
Volume27
Issue number4
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Peripheral Arterial Disease
Cell- and Tissue-Based Therapy
Genetic Therapy
Extremities
Peripheral Vascular Diseases
Therapeutics
Life Expectancy
Amputation
Blood Vessels
Regeneration
Intercellular Signaling Peptides and Proteins
Ischemia
Animal Models
Clinical Trials

Keywords

  • Cell therapy
  • Gene therapy
  • Growth factors
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Regenerative therapy in peripheral artery disease. / Germani, Antonia; Di Campli, Cristiana; Pompilio, Giulio; Biglioli, Paolo; Capogrossi, Maurizio C.

In: Cardiovascular Therapeutics, Vol. 27, No. 4, 12.2009, p. 289-304.

Research output: Contribution to journalArticle

Germani, A, Di Campli, C, Pompilio, G, Biglioli, P & Capogrossi, MC 2009, 'Regenerative therapy in peripheral artery disease', Cardiovascular Therapeutics, vol. 27, no. 4, pp. 289-304. https://doi.org/10.1111/j.1755-5922.2009.00105.x
Germani, Antonia ; Di Campli, Cristiana ; Pompilio, Giulio ; Biglioli, Paolo ; Capogrossi, Maurizio C. / Regenerative therapy in peripheral artery disease. In: Cardiovascular Therapeutics. 2009 ; Vol. 27, No. 4. pp. 289-304.
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