Regenerative therapy in peripheral artery disease

Antonia Germani, Cristiana Di Campli, Giulio Pompilio, Paolo Biglioli, Maurizio C. Capogrossi

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with peripheral artery disease (PAD) and critical limb ischemia are the main candidates for limb amputations and have a poor life expectancy. Frequently, these patients are not eligible for either surgical or percutaneous interventions aimed at mechanical revascularization. Therefore, new strategies need to be identified to offer these patients a viable therapeutic option. Gene and cell therapy hold great promise for the treatment of peripheral vascular diseases because, in animal models, local delivery of growth factors and endothelial progenitor cells result in new blood vessel formation and regeneration of ischemic tissues. In this article, are reviewed phase I and phase II gene, and cell therapy clinical trials in patients with PAD.

Original languageEnglish
Pages (from-to)289-304
Number of pages16
JournalCardiovascular Therapeutics
Volume27
Issue number4
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Cell therapy
  • Gene therapy
  • Growth factors
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)
  • Pharmacology

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