Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: Correlations with delayed enhancement in cardiac magnetic resonance

Research output: Contribution to journalArticle

Abstract

Aims Hypertrophic cardiomyopathy (HCM) is a genetic disease histologically characterized by a profound disarray of myocardial fibres and by local fibrosis. We sought to characterize regional left ventricular contractility in HCM patients using deformation analysis and to compare it with the presence or absence of delayed enhancement in cardiac magnetic resonance (CMR).Methods and resultsWe studied 58 HCM patients (mean age 41 years, 37 male). The control population comprised 15 normal subjects. Colour tissue-Doppler imaging was acquired in two-dimensional mode from apical four-chamber and two-chamber views; off-line analysis was performed in four basal and four middle left ventricular segments. Gadolinium-enhanced CMR was performed in 36 HCM patients. In HCM patients, peak systolic strain was not uniform across left ventricular segments; differences were not related to site or thickness of the segment analysed. Paradoxically, positive systolic strain values were measured in six middle segments. Delayed CMR enhancement was associated with lower peak systolic strain (P = 0.007). Regional non-uniformities in peak systolic strain were not observed in normal subjects.ConclusionAreas of reduced left ventricular contractility in deformation analysis are associated with delayed CMR enhancement in patients with HCM.

Original languageEnglish
Pages (from-to)952-957
Number of pages6
JournalEuropean Journal of Heart Failure
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Cardiac magnetic resonance
  • Hypertrophic cardiomyopathy
  • Systolic deformation
  • Tissue-Doppler imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: Correlations with delayed enhancement in cardiac magnetic resonance'. Together they form a unique fingerprint.

  • Cite this