Regional apparent metabolite concentrations in young adult brain measured by 1H MR spectroscopy at 3 Tesla

Eva H. Baker, Gianpaolo Basso, Peter B. Barker, Mari A. Smith, David Bonekamp, Alena Horská

Research output: Contribution to journalArticle

Abstract

Purpose: To quantify and examine the distribution of brain metabolites in normal young adults using single voxel MR spectroscopy at 3 Tesla (T). Materials and Methods: Short-echo time single-voxel PRESS technique was used to measure the apparent concentration of five metabolites at nine locations in the brains of young adults. Concentrations were estimated by means of an automated fitting method (LCModel) with reference to an unsuppressed water signal and were corrected for T1 relaxation, T2 relaxation, and cerebrospinal fluid partial volume. Analysis of variance with Tukey post hoc test was used to evaluate regional variations. Results: Statistically significant differences in regional concentrations were detected for each of the metabolites. The number of significant differences was greatest for total choline, whereas myo-inositol and the sum of glutamine and glutamate had the fewest. Magnitude of variation was greatest for total choline and least for the sum of N-acetyl aspartate and N-acetylaspartylglutamate. Conclusion: In agreement with previous studies at other field strengths, we found heterogeneous distribution of the major spectroscopically measurable brain metabolites. Although the most distinct differences are between tissue types, there is appreciable variation within a tissue type at different locations. The spectra and metabolite concentrations presented should provide a useful reference for both clinical and research MR spectroscopy studies performed at 3T.

Original languageEnglish
Pages (from-to)489-499
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • 3T
  • Brain metabolites
  • LCModel
  • Magnetic resonance spectroscopy
  • Normal adult

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Regional apparent metabolite concentrations in young adult brain measured by 1H MR spectroscopy at 3 Tesla'. Together they form a unique fingerprint.

  • Cite this