Regional concordance and discordance between rest thallium 201 and sestamibi imaging for assessing tissue viability: Comparison with postrevascularization functional recovery

Paolo Marzullo, Gianmario Sambuceti, Oberdan Parodi, Alessia Gimelli, Eugenio Picano, Assuero Giorgetti, Antonio L'Abbate

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Whether the combined analysis of rest 201Tl and sestamibi uptake provides additional information regarding myocardial viability in patients with coronary artery disease is still to be investigated. Methods and Results: To this aim we studied 22 patients with previous myocardial infarction and regional ventricular dysfunction by quantitative rest sestamibi and 201Tl scintigraphy. All patients underwent revascularization, and echocardiography was repeated 11±2 weeks later. Concordant results were obtained in 80 of 105 dyssynergic segments. Fifty-one segments showed normal and 29 abnormal activity. Follow-up echocardiography showed increased wall motion contractility in 76% of segments with maintained 201Tl and sestamibi uptake and in only 17% of segments characterized by subthreshold activities. Twenty-five segments, or 24%, showed sestamibi/201Tl mismatch. Eleven of 12 segments with normal sestamibi/abnormal 201Tl activity did not improve after revascularization, whereas 11 of 13 segments with abnormal sestamibi but normal 201Tl showed postoperative improvement of regional wall motion. Conclusions: In patients with previous myocardial infarction, sestamibi and 201Tl showed concordant results in most segments. However, in segments with mismatch a maintained sestamibi uptake was a poor indicator of tissue viability, whereas significant 201Tl uptake reflected tissue viability in most segments.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalJournal of Nuclear Cardiology
Volume2
Issue number4
DOIs
Publication statusPublished - Jul 1995

Keywords

  • sestamibi scintigraphy
  • thallium 201 scintigraphy
  • viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Regional concordance and discordance between rest thallium 201 and sestamibi imaging for assessing tissue viability: Comparison with postrevascularization functional recovery'. Together they form a unique fingerprint.

Cite this