Regional cone-mediated dysfunction in age-related maculopathy evaluated by focal electroretinograms: Relationship with retinal morphology and perimetric sensitivity

Marco Piccardi, Lucia Ziccardi, Giovanna Stifano, Lucrezia Montrone, Giancarlo Iarossi, Angelo Minnella, Antonello Fadda, Emilio Balestrazzi, Benedetto Falsini

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess regional cone-mediated function in age-related maculopathy (ARM) by focal electroretinograms (FERGs), and to compare FERGs with morphologic changes and perimetric sensitivity at corresponding locations. Methods: Twenty-six ARM patients and 12 age-matched controls were evaluated. FERGs were elicited by either a central (0-2.25°, C) or a paracentral annular (2.25-9°, PC) flickering (41 Hz) field, presented on a light-adapting background. Morphological changes (soft drusen and/or retinal pigment epithelium defects) at matched locations were assessed by fundus photography and fluorescein angiography. Perimetric sensitivity was measured by Octopus 10° program (tM2). Results: When compared to controls, mean C and PC FERG amplitudes of patients were reduced (p <0.01), and the mean PC FERG phase was delayed (p <0.01). Both FERG delays and morphologic lesions tended to involve to a greater extent the PC compared to the C region. In the C region, perimetric losses were correlated with the extent of morphologic lesions (p <0.05). In the PC region, perimetric losses were correlated with FERG amplitudes (p <0.05). Conclusions: In ARM, FERG losses are eccentricity-dependent, not quantitatively linked to retinal morphology, and correlated with perimetric losses, suggesting a heterogeneous dysfunction with loss of both C and PC perimetric sensitivities.

Original languageEnglish
Pages (from-to)194-202
Number of pages9
JournalOphthalmic Research
Volume41
Issue number4
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Age-related maculopathy
  • Cone-mediated function
  • Drusen
  • Focal electroretinogram
  • Regional dysfunction

ASJC Scopus subject areas

  • Ophthalmology
  • Cellular and Molecular Neuroscience
  • Sensory Systems

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