Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects

J. Norberg, C. Graff, O. Almkvist, M. Ewers, G. B. Frisoni, L. Frölich, H. Hampel, R. W. Jones, P. G. Kehoe, H. Lenoir, L. Minthon, F. Nobili, M. Olde Rikkert, A. S. Rigaud, P. Scheltens, H. Soininen, L. Spiru, M. Tsolaki, L. O. Wahlund, B. VellasG. Wilcock, L. S. Elias-Sonnenschein, F. R J Verhey, P. J. Visser

Research output: Contribution to journalArticle

Abstract

Background: The APOE ε4 allele is a risk factor for Alzheimer's disease (AD). APOE ε4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE ε4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE ε4 prevalence existed in the total sample (62.7% for APOE ε4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE ε4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE ε4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE ε4 allele and cognition is region dependent.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume32
Issue number2
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Alzheimer's disease
  • APOE ε4 allele
  • Europe
  • Gradient

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

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    Norberg, J., Graff, C., Almkvist, O., Ewers, M., Frisoni, G. B., Frölich, L., Hampel, H., Jones, R. W., Kehoe, P. G., Lenoir, H., Minthon, L., Nobili, F., Olde Rikkert, M., Rigaud, A. S., Scheltens, P., Soininen, H., Spiru, L., Tsolaki, M., Wahlund, L. O., ... Visser, P. J. (2011). Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects. Dementia and Geriatric Cognitive Disorders, 32(2), 135-142. https://doi.org/10.1159/000330492