Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

P. Madeddu, V. Anania, P. Pinna Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, N. Glorioso

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalAgents and Actions
Volume38
Issue numberSUPPL. III
DOIs
Publication statusPublished - 1992

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Kinins
Hemodynamics
Rats
Blood
Blood pressure
Bradykinin
Kallikrein-Kinin System
Blood Pressure
Kallikreins
Pharmacology

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Madeddu, P., Anania, V., Pinna Parpaglia, P., Demontis, M. P., Varoni, M. V., Fattaccio, M. C., & Glorioso, N. (1992). Regional hemodynamic effects of a kinin antagonist in awake normotensive rats. Agents and Actions, 38(SUPPL. III), 149-155. https://doi.org/10.1007/BF01976205

Regional hemodynamic effects of a kinin antagonist in awake normotensive rats. / Madeddu, P.; Anania, V.; Pinna Parpaglia, P.; Demontis, M. P.; Varoni, M. V.; Fattaccio, M. C.; Glorioso, N.

In: Agents and Actions, Vol. 38, No. SUPPL. III, 1992, p. 149-155.

Research output: Contribution to journalArticle

Madeddu, P, Anania, V, Pinna Parpaglia, P, Demontis, MP, Varoni, MV, Fattaccio, MC & Glorioso, N 1992, 'Regional hemodynamic effects of a kinin antagonist in awake normotensive rats', Agents and Actions, vol. 38, no. SUPPL. III, pp. 149-155. https://doi.org/10.1007/BF01976205
Madeddu P, Anania V, Pinna Parpaglia P, Demontis MP, Varoni MV, Fattaccio MC et al. Regional hemodynamic effects of a kinin antagonist in awake normotensive rats. Agents and Actions. 1992;38(SUPPL. III):149-155. https://doi.org/10.1007/BF01976205
Madeddu, P. ; Anania, V. ; Pinna Parpaglia, P. ; Demontis, M. P. ; Varoni, M. V. ; Fattaccio, M. C. ; Glorioso, N. / Regional hemodynamic effects of a kinin antagonist in awake normotensive rats. In: Agents and Actions. 1992 ; Vol. 38, No. SUPPL. III. pp. 149-155.
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