Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

P. Madeddu, V. Anania, P. Pinna Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, N. Glorioso

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalAgents and Actions
Volume38
Issue numberSUPPL. III
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Regional hemodynamic effects of a kinin antagonist in awake normotensive rats'. Together they form a unique fingerprint.

Cite this