Abstract
We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.
Original language | English |
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Pages (from-to) | 149-155 |
Number of pages | 7 |
Journal | Agents and Actions |
Volume | 38 |
Issue number | SUPPL. III |
DOIs | |
Publication status | Published - 1992 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology (medical)