Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

P. Madeddu; V. Anania; P. Pinna Parpaglia; M. P. Demontis; M. V. Varoni; M. C. Fattaccio; N. Glorioso

doi:10.1007/BF01976205

Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

P. Madeddu, V. Anania, P. Pinna Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, N. Glorioso

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the effects of the B₂-receptor antagonist Ac-D-Arg[Hyp³,D-Phe⁷,Leu⁸]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.

Original language	English
Pages (from-to)	149-155
Number of pages	7
Journal	Agents and Actions
Volume	38
Issue number	SUPPL. III
DOIs	https://doi.org/10.1007/BF01976205
Publication status	Published - 1992

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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title = "Regional hemodynamic effects of a kinin antagonist in awake normotensive rats",

abstract = "We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.",

author = "P. Madeddu and V. Anania and {Pinna Parpaglia}, P. and Demontis, {M. P.} and Varoni, {M. V.} and Fattaccio, {M. C.} and N. Glorioso",

year = "1992",

doi = "10.1007/BF01976205",

language = "English",

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T1 - Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

AU - Madeddu, P.

AU - Anania, V.

AU - Pinna Parpaglia, P.

AU - Demontis, M. P.

AU - Varoni, M. V.

AU - Fattaccio, M. C.

AU - Glorioso, N.

PY - 1992

Y1 - 1992

N2 - We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.

AB - We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 ± 1% and decreased DMBF by 12 ± 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.

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ER -

Regional hemodynamic effects of a kinin antagonist in awake normotensive rats

Abstract

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