Regional heterogeneity in cardiac sympathetic innervation in acute myocardial infarction: Relationship with myocardial oedema on magnetic resonance

Alessia Gimelli, Pier Giorgio Masci, Riccardo Liga, Chrysanthos Grigoratos, Emilio Maria Pasanisi, Massimo Lombardi, Paolo Marzullo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the relationships between myocardial structure and function on cardiac magnetic resonance (CMR) imaging and sympathetic tone on 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy early after myocardial infarction (MI). Methods: Ten patients underwent 123I-MIBG and 99mTc-tetrofosmin rest cadmium zinc telluride scintigraphy 4±1 days after MI. The segmental left ventricular (LV) relative radiotracer uptake of both 99mTc-tetrofosmin and early 123I-MIBG was calculated. The day after scintigraphy, on CMR imaging, the extent of ischaemia-related oedema and of myocardial fibrosis (late gadolinium enhancement, LGE) was assessed. Accordingly, the extent of oedema and LGE was evaluated for each segment and segmental wall thickening determined. Based on LGE distribution, LV segments were categorized as "infarcted" (56 segments), "adjacent" (66 segments) or "remote" (48 segments). Results: Infarcted segments showed a more depressed systolic wall thickening and greater extent of oedema than adjacent segments (p99mTc-tetrofosmin was significantly depressed only in infarcted segments (p123I-MIBG was impaired not only in infarcted segments (p99mTc-tetrofosmin and LGE distribution, segmental 123I-MIBG uptake (p

Original languageEnglish
Pages (from-to)1692-1694
Number of pages3
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume41
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Cardiac magnetic resonance
  • Cardiac sympathetic tone
  • Myocardial infarction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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