Regional myocardial blood flow in stable angina pectoris associated with isolated significant narrowing of either the left anterior descending or left circumflex coronary artery

Gianmario Sambuceti, Oberdan Parodi, Paolo Marzullo, Assuero Giorgetti, Lucio Fusani, Giacomo Puccini, Piero Salvadori, Antonio L'Abbate

Research output: Contribution to journalArticle

Abstract

Myocardial perfusion measurements were obtained with positron emission tomography under basal conditions and after intravenous dipyridamole infusion (0.56 mg/kg over 4 minutes) to determine if myocardial perfusion is maximized in areas of resting wall motion abnormalities in patients with stable angina. Thirty-three patients with no history of myocardial infarction, and with coronary stenosis >50% involving the left anterior descending (n = 24) and left circumflex (n = 9) coronary arteries were evaluated. Quantitative perfusion images were recorded twice in each subject using nitrogen-13 ammonia at baseline and after intravenous administration of dipyridamole. Computer-assisted analysis of left ventriculograms showed abnormal wall motion in the stenosis-related regions in 16 patients (group 1), and normal regional function in 17 (group 2). The flow values in the anterior and posterolateral wall were considered to reflect left anterior and left circumflex coronary artery flow, respectively. Quantitative angiography showed that coronary stenosis severity was higher in group 1 than in group 2 (cross-sectional area reduction 94 ± 7% vs 87 ± 11%; p

Original languageEnglish
Pages (from-to)990-994
Number of pages5
JournalThe American Journal of Cardiology
Volume72
Issue number14
DOIs
Publication statusPublished - Nov 1 1993

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Stable Angina
Regional Blood Flow
Coronary Vessels
Dipyridamole
Perfusion
Coronary Stenosis
Ammonia
Intravenous Infusions
Intravenous Administration
Positron-Emission Tomography
Angiography
Pathologic Constriction
Nitrogen
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Regional myocardial blood flow in stable angina pectoris associated with isolated significant narrowing of either the left anterior descending or left circumflex coronary artery. / Sambuceti, Gianmario; Parodi, Oberdan; Marzullo, Paolo; Giorgetti, Assuero; Fusani, Lucio; Puccini, Giacomo; Salvadori, Piero; L'Abbate, Antonio.

In: The American Journal of Cardiology, Vol. 72, No. 14, 01.11.1993, p. 990-994.

Research output: Contribution to journalArticle

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