Regional myocardial glucose metabolism in angina pectoris obtained from positron emission tomography

T. J. Spinks, L. I. Araujo, P. Camici

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This article presents a review of studies carried out with positron tomography on myocardial blood flow and glucose metabolism in patients with coronary artery disease and either stable (SA) or unstable angina (UA) pectoris. Regional blood flow was assessed with rubidium 82, an analogue of potassium, and glucose metabolism both with fluorine 18-labeled fluorodeoxyglucose (FDG) and carbon 11-labeled glucose (CG). There were no clear differences in regional myocardial blood flow between SA and UA patients and a group of normal volunteers. FDG uptake was low and homogeneous in both SA patients and normals. In contrast, all UA patients showed abnormally high FDG uptake in at least one left ventricular region at rest in the absence of symptoms or signs of acute ischemia. In the recovery from a period of exercise-induced angina, FDG uptake in SA patients was observed to be higher in previously ischemic regions than in nonischemic regions (as defined by 82Rb). It is postulated that higher FDG uptake in the postischemic myocardium of SA patients is due to repletion of glycogen stores. It remains unclear whether the high uptake in UA patients is due to a recent ischemic episode or is a reflection of a chronic adaptation to repeated stress.

Original languageEnglish
Pages (from-to)56
Number of pages1
JournalJournal of Thoracic Imaging
Volume3
Issue number2
Publication statusPublished - 1988

Fingerprint

Angina Pectoris
Positron-Emission Tomography
Glucose
Unstable Angina
Stable Angina
Regional Blood Flow
Rubidium
Fluorodeoxyglucose F18
Glycogen
Signs and Symptoms
Blood Glucose
Coronary Artery Disease
Myocardium
Healthy Volunteers
Potassium
Carbon
Ischemia
Tomography
Electrons
Exercise

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Regional myocardial glucose metabolism in angina pectoris obtained from positron emission tomography. / Spinks, T. J.; Araujo, L. I.; Camici, P.

In: Journal of Thoracic Imaging, Vol. 3, No. 2, 1988, p. 56.

Research output: Contribution to journalArticle

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