Abstract
Locally advanced osteogenic sarcoma of the extremities always offers poor results in term of local response and overall survival. The aim of this paper is to present long term results of two series of patients treated with hyperthermic perfusion (HP). Patients are divided into two groups: one with the goal of limb salvage and the second, represented by patients with concurrent lung metastases, where local control in order to avoid amputations, was the goal. In the first group of 16 patients limb salvage was obtained in 13 patients, with good results in term of necrosis of the primary tumour. The second group, with 7 patients, also demonstrated a good outcome: the mean survival was 14 months, with an optimal local control of disease, without any pathological fractures and consequently a good quality of life. In conclusion: HP can play an important role in controlling primary advanced osteogenic sarcoma not responding to pre-operative chemotherapy. The synergistic effect between hyperthermia (41-41,5 °C) and high dose cis-platinum makes it possible to achieve limb salvage.
| Original language | English |
|---|---|
| Pages (from-to) | 106-110 |
| Number of pages | 5 |
| Journal | Regional Cancer Treatment |
| Volume | 7 |
| Issue number | 2 |
| Publication status | Published - 1995 |
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Keywords
- Hyperthermia
- Limb salvage
- Osteogenic sarcoma
- Regional perfusion
ASJC Scopus subject areas
- Oncology
- Pharmacology
Cite this
Regional perfusion for osteogenic sarcoma of extremities. Long term results for limb salvage in primary advanced disease-and local control in presence of lung metastases. / Vaglini, M.; Belli, F.; Carraro, O.; Deraco, M.; Mascheroni, L.; Persiani, L.; Prada, A.; Santoro, N.; Santinami, M.
In: Regional Cancer Treatment, Vol. 7, No. 2, 1995, p. 106-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional perfusion for osteogenic sarcoma of extremities. Long term results for limb salvage in primary advanced disease-and local control in presence of lung metastases
AU - Vaglini, M.
AU - Belli, F.
AU - Carraro, O.
AU - Deraco, M.
AU - Mascheroni, L.
AU - Persiani, L.
AU - Prada, A.
AU - Santoro, N.
AU - Santinami, M.
PY - 1995
Y1 - 1995
N2 - Locally advanced osteogenic sarcoma of the extremities always offers poor results in term of local response and overall survival. The aim of this paper is to present long term results of two series of patients treated with hyperthermic perfusion (HP). Patients are divided into two groups: one with the goal of limb salvage and the second, represented by patients with concurrent lung metastases, where local control in order to avoid amputations, was the goal. In the first group of 16 patients limb salvage was obtained in 13 patients, with good results in term of necrosis of the primary tumour. The second group, with 7 patients, also demonstrated a good outcome: the mean survival was 14 months, with an optimal local control of disease, without any pathological fractures and consequently a good quality of life. In conclusion: HP can play an important role in controlling primary advanced osteogenic sarcoma not responding to pre-operative chemotherapy. The synergistic effect between hyperthermia (41-41,5 °C) and high dose cis-platinum makes it possible to achieve limb salvage.
AB - Locally advanced osteogenic sarcoma of the extremities always offers poor results in term of local response and overall survival. The aim of this paper is to present long term results of two series of patients treated with hyperthermic perfusion (HP). Patients are divided into two groups: one with the goal of limb salvage and the second, represented by patients with concurrent lung metastases, where local control in order to avoid amputations, was the goal. In the first group of 16 patients limb salvage was obtained in 13 patients, with good results in term of necrosis of the primary tumour. The second group, with 7 patients, also demonstrated a good outcome: the mean survival was 14 months, with an optimal local control of disease, without any pathological fractures and consequently a good quality of life. In conclusion: HP can play an important role in controlling primary advanced osteogenic sarcoma not responding to pre-operative chemotherapy. The synergistic effect between hyperthermia (41-41,5 °C) and high dose cis-platinum makes it possible to achieve limb salvage.
KW - Hyperthermia
KW - Limb salvage
KW - Osteogenic sarcoma
KW - Regional perfusion
UR - http://www.scopus.com/inward/record.url?scp=0028878222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028878222&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028878222
VL - 7
SP - 106
EP - 110
JO - Regional Cancer Treatment
JF - Regional Cancer Treatment
SN - 0935-0411
IS - 2
ER -