Regional perfusion for osteogenic sarcoma of extremities. Long term results for limb salvage in primary advanced disease-and local control in presence of lung metastases

M. Vaglini, F. Belli, O. Carraro, M. Deraco, L. Mascheroni, L. Persiani, A. Prada, N. Santoro, M. Santinami

Research output: Contribution to journalArticle

Abstract

Locally advanced osteogenic sarcoma of the extremities always offers poor results in term of local response and overall survival. The aim of this paper is to present long term results of two series of patients treated with hyperthermic perfusion (HP). Patients are divided into two groups: one with the goal of limb salvage and the second, represented by patients with concurrent lung metastases, where local control in order to avoid amputations, was the goal. In the first group of 16 patients limb salvage was obtained in 13 patients, with good results in term of necrosis of the primary tumour. The second group, with 7 patients, also demonstrated a good outcome: the mean survival was 14 months, with an optimal local control of disease, without any pathological fractures and consequently a good quality of life. In conclusion: HP can play an important role in controlling primary advanced osteogenic sarcoma not responding to pre-operative chemotherapy. The synergistic effect between hyperthermia (41-41,5 °C) and high dose cis-platinum makes it possible to achieve limb salvage.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalRegional Cancer Treatment
Volume7
Issue number2
Publication statusPublished - 1995

Fingerprint

Limb Salvage
Osteosarcoma
Extremities
Perfusion
Neoplasm Metastasis
Lung
Spontaneous Fractures
Survival
Amputation
Cisplatin
Fever
Necrosis
Quality of Life
Drug Therapy
Neoplasms

Keywords

  • Hyperthermia
  • Limb salvage
  • Osteogenic sarcoma
  • Regional perfusion

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

Cite this

Regional perfusion for osteogenic sarcoma of extremities. Long term results for limb salvage in primary advanced disease-and local control in presence of lung metastases. / Vaglini, M.; Belli, F.; Carraro, O.; Deraco, M.; Mascheroni, L.; Persiani, L.; Prada, A.; Santoro, N.; Santinami, M.

In: Regional Cancer Treatment, Vol. 7, No. 2, 1995, p. 106-110.

Research output: Contribution to journalArticle

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AU - Deraco, M.

AU - Mascheroni, L.

AU - Persiani, L.

AU - Prada, A.

AU - Santoro, N.

AU - Santinami, M.

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