Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy

Collaborative Group for the Point Prevalence Survey of healthcare-associated infections in Liguria

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Given the importance of monitoring healthcare-associated infections (HCAIs) and the consumption of antibiotics, a regional point prevalence survey was conducted in Liguria between March and April 2016.

AIM: To measure the overall prevalence of HCAI and describe the use of antibiotics in all public hospitals.

METHODS: Data on risk factors and use of antibiotics were collected for each hospitalized patient. To define the variables significantly associated with HCAI, univariate and multivariate analyses were conducted. Standardized infection ratio and standardized antimicrobial use ratio were measured for each participating hospital.

FINDINGS: A total of 3647 patients were enrolled. In all, 429 HCAIs were diagnosed in 376 patients, giving a prevalence of HCAI of 10.3%. Respiratory tract (21.7%) and urinary tract (20%) were the most frequent sites of infection. High rates of meticillin-resistant Staphylococcus aureus (47.4%) and Enterobacteriaceae resistant to carbapenems (26.3%) were isolated. Forty-six percent of patients received at least one antibiotic. Combinations of penicillins including β-lactamase inhibitors (24.1%) were the most widely used; the main indication (46.7%) was the treatment of a community-acquired infection.

CONCLUSION: There was an increase in HCAI prevalence compared to a similar survey conducted in 2007; however, the performance of overlapping investigations will enable more reliable considerations. Nevertheless, data on antimicrobial resistance and use of antibiotics are consistent with the national trend. Despite methodological limitations, prevalence studies are useful to monitor HCAI over time and encourage greater awareness of the problem by all stakeholders.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalJournal of Hospital Infection
Volume99
Issue number1
DOIs
Publication statusPublished - May 2018

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Cross Infection
Italy
Cross-Sectional Studies
Anti-Bacterial Agents
Community-Acquired Infections
Carbapenems
Methicillin
Public Hospitals
Enterobacteriaceae
Microbial Drug Resistance
Infection
Urinary Tract
Penicillins
Respiratory System
Staphylococcus aureus
Multivariate Analysis

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents/therapeutic use
  • Child
  • Child, Preschool
  • Cross Infection/epidemiology
  • Drug Utilization
  • Enterobacteriaceae/isolation & purification
  • Enterobacteriaceae Infections/epidemiology
  • Female
  • Hospitals, Public
  • Humans
  • Infant
  • Infant, Newborn
  • Italy/epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Staphylococcal Infections/epidemiology
  • Staphylococcus aureus/isolation & purification
  • Surveys and Questionnaires
  • Young Adult

Cite this

Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy. / Collaborative Group for the Point Prevalence Survey of healthcare-associated infections in Liguria.

In: Journal of Hospital Infection, Vol. 99, No. 1, 05.2018, p. 8-16.

Research output: Contribution to journalArticle

Collaborative Group for the Point Prevalence Survey of healthcare-associated infections in Liguria 2018, 'Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy', Journal of Hospital Infection, vol. 99, no. 1, pp. 8-16. https://doi.org/10.1016/j.jhin.2017.12.008
Collaborative Group for the Point Prevalence Survey of healthcare-associated infections in Liguria. / Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy. In: Journal of Hospital Infection. 2018 ; Vol. 99, No. 1. pp. 8-16.
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TY - JOUR

T1 - Regional point prevalence study of healthcare-associated infections and antimicrobial use in acute care hospitals in Liguria, Italy

AU - Collaborative Group for the Point Prevalence Survey of healthcare-associated infections in Liguria

AU - Sticchi, C

AU - Alberti, M

AU - Artioli, S

AU - Assensi, M

AU - Baldelli, I

AU - Battistini, A

AU - Boni, S

AU - Cassola, G

AU - Castagnola, Elio

AU - Cattaneo, M

AU - Cenderello, N

AU - Cristina, M L

AU - De Mite, A M

AU - Fabbri, P

AU - Federa, F

AU - Giacobbe, D R

AU - La Masa, D

AU - Lorusso, C

AU - Marioni, K

AU - Masi, V M

AU - Mentore, B

AU - Montoro, S

AU - Orsi, A

AU - Raiteri, D

AU - Riente, R

AU - Samengo, I

AU - Viscoli, C

AU - Carloni, R

N1 - Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Given the importance of monitoring healthcare-associated infections (HCAIs) and the consumption of antibiotics, a regional point prevalence survey was conducted in Liguria between March and April 2016.AIM: To measure the overall prevalence of HCAI and describe the use of antibiotics in all public hospitals.METHODS: Data on risk factors and use of antibiotics were collected for each hospitalized patient. To define the variables significantly associated with HCAI, univariate and multivariate analyses were conducted. Standardized infection ratio and standardized antimicrobial use ratio were measured for each participating hospital.FINDINGS: A total of 3647 patients were enrolled. In all, 429 HCAIs were diagnosed in 376 patients, giving a prevalence of HCAI of 10.3%. Respiratory tract (21.7%) and urinary tract (20%) were the most frequent sites of infection. High rates of meticillin-resistant Staphylococcus aureus (47.4%) and Enterobacteriaceae resistant to carbapenems (26.3%) were isolated. Forty-six percent of patients received at least one antibiotic. Combinations of penicillins including β-lactamase inhibitors (24.1%) were the most widely used; the main indication (46.7%) was the treatment of a community-acquired infection.CONCLUSION: There was an increase in HCAI prevalence compared to a similar survey conducted in 2007; however, the performance of overlapping investigations will enable more reliable considerations. Nevertheless, data on antimicrobial resistance and use of antibiotics are consistent with the national trend. Despite methodological limitations, prevalence studies are useful to monitor HCAI over time and encourage greater awareness of the problem by all stakeholders.

AB - BACKGROUND: Given the importance of monitoring healthcare-associated infections (HCAIs) and the consumption of antibiotics, a regional point prevalence survey was conducted in Liguria between March and April 2016.AIM: To measure the overall prevalence of HCAI and describe the use of antibiotics in all public hospitals.METHODS: Data on risk factors and use of antibiotics were collected for each hospitalized patient. To define the variables significantly associated with HCAI, univariate and multivariate analyses were conducted. Standardized infection ratio and standardized antimicrobial use ratio were measured for each participating hospital.FINDINGS: A total of 3647 patients were enrolled. In all, 429 HCAIs were diagnosed in 376 patients, giving a prevalence of HCAI of 10.3%. Respiratory tract (21.7%) and urinary tract (20%) were the most frequent sites of infection. High rates of meticillin-resistant Staphylococcus aureus (47.4%) and Enterobacteriaceae resistant to carbapenems (26.3%) were isolated. Forty-six percent of patients received at least one antibiotic. Combinations of penicillins including β-lactamase inhibitors (24.1%) were the most widely used; the main indication (46.7%) was the treatment of a community-acquired infection.CONCLUSION: There was an increase in HCAI prevalence compared to a similar survey conducted in 2007; however, the performance of overlapping investigations will enable more reliable considerations. Nevertheless, data on antimicrobial resistance and use of antibiotics are consistent with the national trend. Despite methodological limitations, prevalence studies are useful to monitor HCAI over time and encourage greater awareness of the problem by all stakeholders.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Bacterial Agents/therapeutic use

KW - Child

KW - Child, Preschool

KW - Cross Infection/epidemiology

KW - Drug Utilization

KW - Enterobacteriaceae/isolation & purification

KW - Enterobacteriaceae Infections/epidemiology

KW - Female

KW - Hospitals, Public

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Italy/epidemiology

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Staphylococcal Infections/epidemiology

KW - Staphylococcus aureus/isolation & purification

KW - Surveys and Questionnaires

KW - Young Adult

U2 - 10.1016/j.jhin.2017.12.008

DO - 10.1016/j.jhin.2017.12.008

M3 - Article

C2 - 29253622

VL - 99

SP - 8

EP - 16

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

IS - 1

ER -