Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging

Alessandro Bertolino, Safia Nawroz, Venkata S. Mattay, Alan S. Barnett, Jozef H. Duyn, Chrit T W Moonen, Joseph A. Frank, Gioacchino Tedeschi, Daniel R. Weinberger

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Objective: Several single-voxel proton magnetic resonance spectroscopy (1H-MRS) studies of patients with schizophrenia have found evidence of reductions of N-acetyl-aspartate (NAA) concentrations in the temporal lobes. Multislice proton spectroscopy imaging (1H-MRSI) permits simultaneous acquisition and mapping of NAA, choline-containing compounds (CHO), and creatine/phosphocreatine (CRE) signal intensities from multiple whole brain slices consisting of 1.4-ml single-volume elements. We have used 1H-MRSI to assess the regional specificity of previously reported changes of metabolite signal intensities in schizophrenia. Hippocampal volume was also measured to test the relationship between 1H-MRSI findings and tissue volume in this region. Method: Ratios of areas under the metabolite peaks of the proton spectra were determined (i.e., NAA/CRE, NAA/CHO, CHO/CRE) for multiple cortical and subcortical regions in 10 inpatients with schizophrenia. Results: Patients showed significant reductions of NAA/CRE and NAA/CHO bilaterally in the hippocampal region and in the dorsolateral prefrontal cortex. There were no significant changes in CHO/CRE or in NAA ratios in any other area sampled. No significant correlations was found between metabolite ratios in the hippocampal region and its volume. Conclusions: NAA-relative signal intensity reductions in schizophrenia appear to be remarkably localized, involving primarily the hippocampal region and the dorsolateral prefrontal cortex, two regions implicated prominently in the pathophysiology of this disorder.

Original languageEnglish
Pages (from-to)1554-1563
Number of pages10
JournalAmerican Journal of Psychiatry
Volume153
Issue number12
Publication statusPublished - Dec 1996

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Protons
Schizophrenia
Phosphocreatine
Magnetic Resonance Imaging
Creatine
Pathology
Prefrontal Cortex
N-acetylaspartate
Temporal Lobe
Choline
Inpatients
Spectrum Analysis
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bertolino, A., Nawroz, S., Mattay, V. S., Barnett, A. S., Duyn, J. H., Moonen, C. T. W., ... Weinberger, D. R. (1996). Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. American Journal of Psychiatry, 153(12), 1554-1563.

Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. / Bertolino, Alessandro; Nawroz, Safia; Mattay, Venkata S.; Barnett, Alan S.; Duyn, Jozef H.; Moonen, Chrit T W; Frank, Joseph A.; Tedeschi, Gioacchino; Weinberger, Daniel R.

In: American Journal of Psychiatry, Vol. 153, No. 12, 12.1996, p. 1554-1563.

Research output: Contribution to journalArticle

Bertolino, A, Nawroz, S, Mattay, VS, Barnett, AS, Duyn, JH, Moonen, CTW, Frank, JA, Tedeschi, G & Weinberger, DR 1996, 'Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging', American Journal of Psychiatry, vol. 153, no. 12, pp. 1554-1563.
Bertolino, Alessandro ; Nawroz, Safia ; Mattay, Venkata S. ; Barnett, Alan S. ; Duyn, Jozef H. ; Moonen, Chrit T W ; Frank, Joseph A. ; Tedeschi, Gioacchino ; Weinberger, Daniel R. / Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. In: American Journal of Psychiatry. 1996 ; Vol. 153, No. 12. pp. 1554-1563.
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