Regioselective halogenation of aminopyrimidinyl-pyrrole carboxylic acid derivatives

Ermes Vanotti, Marina Caldarelli, Teresa Disingrini, Marcella Nesi, Marco Tatò, Paola Vianello, Maria Menichincheri

Research output: Contribution to journalArticle

Abstract

The regioselective synthesis of halogenated aminopyrimidinyl-pyrroles as useful scaffolds for the preparation of diversified selective kinase inhibitors is described. The chemistry is simple and mostly based on the use of N-halosuccinimides under mild reaction conditions but the regioselectivity observed is partially unexpected.

Original languageEnglish
Pages (from-to)10418-10423
Number of pages6
JournalTetrahedron
Volume65
Issue number50
DOIs
Publication statusPublished - Dec 12 2009

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Keywords

  • Halogenation
  • Kinase inhibitors
  • N-Halosuccinimide
  • Pyrimidine
  • Pyrrole

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Vanotti, E., Caldarelli, M., Disingrini, T., Nesi, M., Tatò, M., Vianello, P., & Menichincheri, M. (2009). Regioselective halogenation of aminopyrimidinyl-pyrrole carboxylic acid derivatives. Tetrahedron, 65(50), 10418-10423. https://doi.org/10.1016/j.tet.2009.10.030