Registration of adaptive optics corrected retinal nerve fiber layer (RNFL) images

Gomathy Ramaswamy, Marco Lombardo, Nicholas Devaney

Research output: Contribution to journalArticlepeer-review


Glaucoma is the leading cause of preventable blindness in the western world. Investigation of high-resolution retinal nerve fiber layer (RNFL) images in patients may lead to new indicators of its onset. Adaptive optics (AO) can provide diffraction-limited images of the retina, providing new opportunities for earlier detection of neuroretinal pathologies. However, precise processing is required to correct for three effects in sequences of AO-assisted, flood-illumination images: uneven illumination, residual image motion and image rotation. This processing can be challenging for images of the RNFL due to their low contrast and lack of clearly noticeable features. Here we develop specific processing techniques and show that their application leads to improved image quality on the nerve fiber bundles. This in turn improves the reliability of measures of fiber texture such as the correlation of Gray-Level Co-occurrence Matrix (GLCM).

Original languageEnglish
Pages (from-to)1941-1951
Number of pages11
JournalBiomedical Optics Express
Issue number6
Publication statusPublished - May 22 2014

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology


Dive into the research topics of 'Registration of adaptive optics corrected retinal nerve fiber layer (RNFL) images'. Together they form a unique fingerprint.

Cite this