Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: Biological correlates of clinical outcome

A. M. Cattelan, M. L. Calabro', S. M L Aversa, M. Zanchetta, F. Meneghetti, A. De Rossi, L. Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical response of AIDS-related Kaposi's sarcoma (KS) to highly active antiretroviral therapy (HAART), a combination of human immunodeficiency virus type 1 (HIV-1) protease and reverse transcriptase inhibitors, was studied in 11 patients, all but one with progressive KS. CD4 + cell counts, plasma HIV-1 RNA levels, and antibody titres to lytic ORF65 and latency-associated human herpes virus type 8 (HHV-8) proteins were determined in sequential samples. Six complete and three partial clinical responses were achieved in a median time of 6 and 3 months, respectively, and confirmed after a median time of 16 months on HAART. 2 patients showed disease progression. A consistent decrease in HIV-1 RNA levels, paralleled by an increase in CD4 + cell counts, was observed in all patients who showed complete or partial clinical response; HIV-1 RNA levels remained persistently high in the two patients who progressed, despite a change in HAART. HHV-8 antibody titres were generally higher in patients with mucosal/visceral involvement compared with patients with limited disease; a decrease in ORF65 antibody titre was significantly associated with a clinical response. These results indicate that HAART is effective for AIDS-related KS; the clinical response correlates with a decrease in plasma HIV-1 RNA levels, an increase in CD4 + lymphocytes, and a decrease in antibodies to ORF65 HHV-8 protein.

Original languageEnglish
Pages (from-to)1809-1815
Number of pages7
JournalEuropean Journal of Cancer
Volume35
Issue number13
DOIs
Publication statusPublished - Dec 1999

Keywords

  • HAART
  • HHV-8 antibodies
  • HIV-1
  • Kaposi's sarcoma
  • Protease inhibitors

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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